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Please note that we are not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Analysis of Gene Mutations in Tumors

Cancer is a complex disease driven by the accumulation of genetic alterations in key genes and signaling pathways. The identification and characterization of these mutations are essential for understanding the underlying biology of the disease and developing targeted therapies. At Alfa Cytology, we delve deep into the genetic makeup of tumors to provide invaluable insights into cancer research.

Introduction to Gene Mutations in Tumors

Tumor-associated gene mutations can be broadly classified into two categories: inherited (germline) mutations and acquired (somatic) mutations. Inherited mutations are present in every cell of the body and are passed down from generation to generation, while acquired mutations arise spontaneously during an individual's lifetime, often due to environmental factors or replication errors.

Fig 1. The role of mutation and the genes that play a vital role in cancer development Fig.1 The role of mutation and the genes that play a vital role in cancer development. (Paul, P., et al., 2019)

Role of Different Gene Types

These genetic changes can occur in various types of genes, each with a distinct role in regulating cellular function.

Gene Type	Description
Tumor Suppressor Genes	Mutations in genes like TP53 and PTEN can lead to the uncontrolled proliferation of cells.
Oncogenes	Alterations in genes like KRAS and BRAF can drive the transformation of healthy cells into cancerous ones.
DNA Repair Genes	Mutations in genes such as BRCA1 and BRCA2 can compromise the cell's ability to maintain genomic integrity, further contributing to the accumulation of genetic aberrations.

Our Services

Alfa Cytology provides a comprehensive range of services to identify and characterize the genetic alterations present within the tumor and its microenvironment. Our services include, but are not limited to:

Targeted Gene Panel Sequencing

High-throughput sequencing of key cancer-related genes.
Identification of single nucleotide variants (SNVs), insertions, deletions, and copy number variations.

Whole Exome Sequencing (WES)

Comprehensive analysis of coding regions in the genome.
Detection of novel and rare mutations across the exome.

Whole Genome Sequencing (WGS)

Complete genetic landscape analysis.
Identification of structural variations, complex rearrangements, and non-coding region mutations.

Custom Mutation Analysis

Tailored analysis based on specific research needs.
Focus on particular gene sets or mutation hotspots.

For a comprehensive overview of cancer genomic landscape, we offer a comprehensive suite of genomics services for cancer research. Our state-of-the-art technologies and expertise enable us to provide invaluable insights into disease mechanisms and therapeutic targets.

Our Advantages

Comprehensive Mutation Discovery: By combining mutation data with gene expression profiles, we can uncover a wider range of cancer-associated genetic alterations, including those that may have been missed by recurrence-based methods.
Improved Therapeutic Targeting: Our ability to identify low-prevalence, yet biologically relevant, genetic drivers provide our clients with valuable insights for the development of targeted cancer therapies.
Customized Solutions: We work closely with our clients to tailor our services to their specific needs, ensuring that our analysis delivers actionable insights that directly address their research goals.
Experienced Team: Our team of renowned experts in cancer genomics, bioinformatics, and computational biology bring a wealth of knowledge and expertise to every project, ensuring the highest quality of service and data interpretation.

At Alfa Cytology, we are dedicated to unlocking the genetic secrets of tumors, providing our clients with the critical insights necessary to unravel the complexities of gene mutations and make significant contributions to the field of cancer research. If you are interested in our service, please contact us for more details.

Reference

Paul, P., et al.; (2019). The significance of gene mutations across eight major cancer types. Mutation Research/Reviews in Mutation Research, 781, 88-99.

For research use only.