Cell Line Development Services for Meningioma

Meningioma is the most common form of primary brain tumor, accounting for approximately 30% of all brain tumors. It is primarily low-grade and may become cancerous over time, transforming from cells in the meninges that protect the brain and spinal cord. In vitro studies of the cellular functions and mechanisms of malignant meningiomas, as well as in vivo studies, are essential in the search for new therapeutic approaches for malignant tumors and the translation of basic research into clinical applications.

We offer services for meningioma cell line development

Alfa Cytology can culture stable malignant meningioma primary cells to isolate and culture meningioma cell lines of uniform cell quality. They are identified by immunofluorescence and other assays that match the characteristics of meningioma cells. We can also perform cell viability and cell morphology assays by MTT and bright-field microscopy and examine adhesion chemotaxis, and invasion by real-time cell analysis.

Successfully developed meningioma cell lines

STR identification of meningioma cell lines

During scientific research, the use of cross-contaminated or misidentified cells will lead to serious problems such as wrong research conclusions, non-reproducible results, and disastrous consequences of clinical therapy. STR genotyping can be used as the gold standard for cell identification.

The alleles on the STR gene seat can be distinguished by the difference in copy number of repetitive sequences in the PCR amplified region. We match the resulting STR typing results with STR data of cell lines from multiple databases to derive the name of the cell line to which the sample belongs or the cell line with possible cross-contamination. We can provide STR identification service for meningioma cell lines with reliable data and a short experimental cycle time.

• Cell species identification
• Cell recovery and culture
• Other cell identification-related services

Applications

• Establishment of intracranial graft retention tumor model in mice with malignant meningioma.
• Study of the mechanisms by which signaling pathways regulate the proliferation of malignant meningioma cells.
• Validation of the efficacy of monoclonal antibodies or other drugs specifically targeting meningiomas and other related drug evaluation.
• Study of the mechanisms driving the development and aggressive growth of meningiomas.
• Antiretroviral drug therapy studies.

Alfa Cytology offers a simple and easy-to-use method for isolating and culturing meningioma cells, and the isolated cells can be stably passaged to facilitate experimental studies on meningioma cell characteristics. The meningioma cell lines we have developed are good experimental tools for laboratory studies on the pathogenesis of meningioma-grade metastasis, and also provide a model for clinical studies on meningioma prevention. Please contact our staff to select the right cell line for your meningioma research.