Chemokine Analysis Services for Brain Tumors

Chemokine receptors and their ligands are widely involved in the pathophysiological process of tumor growth and progression, making them attractive therapeutic targets to explore. Alfa Cytology offers tailored chemokine analysis services to support your research.

Introduction to Chemokine

Chemokines are chemotactic cytokines that govern the migration, adhesion and cell-cell interaction of immune cells. There are approximately 50 known chemokines categorized into four primary classes based on the positioning of the first two cysteine residues in their primary protein structure, namely the C, the CC, the CXC and the CX3C chemokines.

Chemokines in Brain Tumors

Chemokines are widely engaged in carcinogenesis and exhibit a bidirectional role in the development of brain tumors, including immune evasion, tumor proliferation, angiogenesis and metastasis. Chemokines such as CXCL10 chemokine axes can direct immune cell trafficking and then guide the spatial organization and anti-tumor immune response in the brain tumor microenvironment. On the other hand, other chemokine systems such as CCR8 chemokine axes can facilitate the differentiation and migration of immunosuppressive cells and tumor-associated macrophages, contributing to a pro-tumorigenic microenvironment in brain tumors.

Fig.1 Chemokines in pro-tumor immunity. (Bule P., et al., 2021)

Our Services

Equipped with a high throughput flow cytometer, Alfa Cytology can provide advanced brain tumor related chemokine analysis services to our clients.

Our Services Help You Achieve the Following Goals

• Predict and identify key transcriptional regulators and kinase targets.
• Explore the correlation between immune cell infiltration and gene expression.

Advantages of Our Chemokine Analysis

• The chemokine assays we provided are conducted in both single and multiplexed formats with high sensitivity, a broad dynamic range and enhanced convenience.
• A variety of sample matrices including cell cultures, serum, plasma and cerebrospinal fluid are accommodated for our chemokine detection services.
• Minimal sample volumes are needed for our chemokine detection, allowing for the simultaneous detection of multiple analytes. This not only enhances drug screening efficiency but also enables the implementation of novel analytical methods.

Contact Us

The complex interactions between chemokine receptors and their ligands require an in-depth understanding of brain tumor microenvironment biology. Alfa Cytology provides professional chemokine analysis services tailored to your specific needs. Please feel free to contact us to discuss any project related to chemokines in brain tumors.

Reference

1. Bule P.; et al. (2021). Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy[J]. International journal of molecular sciences. 22(18), 9804.