Customized Services for Special Brain Tumors Model

Animal models play a critical role in basic research on brain tumorigenesis, development, and metastasis, as well as drug development and treatment. With the animal models established by Alfa Cytology, you can study the origin, differentiation, and aging process of neural cells, the mechanism of synapse and neural loop formation, the role of glial cells in the function of the nervous system, and the pathogenesis of glioma and cerebral aneurysm (CA).

We provide customization services for special brain tumors model

CA animal models

The pathophysiological mechanism of CA formation and rupture is still unclear. the application of CA animal models is crucial to your understanding of the biological mechanism of CA and the search for therapeutic approaches. We have established CA models for several species, including mice, rats, rabbits, pigs, sheep, dogs, and primates, each with its advantages and limitations, so you can choose the suitable animal model for your research purposes. With our animal models, you can attempt to replicate the morphological, histological, and hemodynamic characteristics of human CA, which can be used to study aneurysm formation, growth, and rupture, as well as to test the efficacy of new treatment modalities.

Small animal CA models

Our rodent CA models are an important tool for studying the molecular mechanisms of CA formation, progression, and rupture. You can study specific proteins altered in human CA with transgenic mice.

Large animal CA models

This provides you with a wide range of uses for studying endovascular therapies, aneurysm healing, and endovascular treatments. In large animal models, the venous pocket aneurysm model allows the selection of aneurysm size, morphology, and location, and aneurysms can form in vessels with diameters and blood flow similar to those of human cerebral arteries.

Large animal models for glioma

Large animal models overcome many of the anatomical and physiological limitations of simulating human disease in rodents. While large animal models are not a substitute for rodent studies, they can serve as a transitional step in treatment development and can better replicate human physiology, thereby increasing the success of clinical trials. Glioma clinical trials are costly and long-lasting but have low success rates. We offer large animal models that can bridge the translational gap between basic research and clinical trials. The anatomy and physiology of large animals are more similar to humans and can be used in trials such as glioma surgery and adjuvant therapy.

• Pig model. The pig is the most abundant and versatile large animal used as a glioma model. The porcine brain has a cerebral gyrus that reflects tumor infiltration, drug delivery, and drug diffusion within the human brain cortex and cortical structures. Porcine brain size offers significant advantages in high-resolution imaging of the brain.
• Dog model. Glioma is the most common primary malignant brain tumor in dogs, and canine glioblastoma is similar to that in humans. Experiments have also confirmed that canine gliomas are similar to human childhood gliomas in terms of driver mutations, the timing of mutations, and epigenetic patterns.
• Non-human primate (NHP) models. NHPs are most similar to humans physiologically, anatomically, and genetically, with near 1:1 homology between genomes. The long latency period of tumorigenesis is similar to that of humans, which helps to study the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs.

If you are interested in the above animal models please feel free to contact our staff and we will help you to build customized models for brain tumor research.