Growth Factor Analysis Services for Brain Tumors

Growth factors play a pivotal role in cell homeostasis. However, overexpression of certain growth factors such as colony-stimulating factors (CSFs) and epidermal growth factors (EGFs) can lead to uncontrolled proliferation and malignant transformation of specific cells, which can eventually transform into tumor cells. At Alfa Cytology, we offer professional growth factor analysis services tailored to your research.

Growth Factors in Brain Tumors

Growth factors are a diverse group of multifunctional secreted peptides that include platelet-derived growth factors (PDGFs), epidermal growth factors (EGFs), transforming growth factors (TGFs), fibroblast growth factors (FGFs), insulin-like growth factors (IGFs), interleukins, nerve growth factors (NGFs), erythropoietin (EPO) and colony-stimulating factors (CSFs). These signaling molecules are essential elements in regulating brain cell proliferation and wound healing under physiological conditions. Dysregulation of growth factors in the brain can contribute to brain tumor proliferation, metastasis and drug resistance, making the investigation of growth factors a hotspot in brain tumor research.

Fig.1 The roles of TGF-β and BMP in the glioblastoma microenvironment. (Golán-Cancela I., & Caja L, 2024)

Our Services

Alfa Cytology integrates enzyme-linked immunosorbent assay (ELISA), microsphere technology and flow cytometry to offer a high-throughput assay capable of analyzing multiple growth factors in a limited number of samples simultaneously. In contrast to conventional ELISA methods, which typically assess a single indicator per specimen, microsphere-based multiplex assays can concurrently detect multiple indicators from a single sample, saving samples and enhancing research efficiency.

Growth Factors We Can Test

Specializing in employing established methods for analyzing a wide spectrum of growth factors, our growth factor analysis services are regarded for high sensitivity and excellent reproducibility and are customized specifically for brain tumor research. The growth factors we are able to test include but are not limited to the following components.

• Platelet-derived growth factors (PDGFs) and osteosarcoma-derived growth factor (ODGF)
• Epidermal growth factors (EGFs)
• Transforming growth factors (TGFs) such as TGF-α and TGF-β
• Fibroblast growth factors (FGFs) such as the FGF1 subfamily, FGF4 subfamily, FGF7 subfamily, FGF8 subfamily and the FGF9 subfamily
• Insulin-like growth factors (IGFs) such as IGF-1 and IGF-2
• Interleukins such as IL-1, IL-2 and IL-3
• Nerve growth factors (NGFs)
• Erythropoietin (EPO)
• Colony-stimulating factors (CSFs) such as M-CSF and G-CSF

Our Services Help You Achieve the Following Goals

• Analyze the immune function of the body, assist in the diagnosis of brain tumors and monitor the disease process, treatment and prognosis.
• Facilitate the discovery of novel biomarkers and the elucidation of mechanisms involved in the development of brain tumors.

Workflow of Growth Factor Analysis

Customer Inquiry

Project Initiation

Method Development

Sample Measurement

Data Analysis

Advantages of Our Growth Factor Analysis

• Less specimen volume. With a requirement of only 15 μL of specimen volume, we can analyze multiple indicators accurately and efficiently.
• Same sensitivity but with a wider range. We have extended the range of tests to ensure maximum specimen applicability.
• Free combination of assays. Allowing you to freely combine assays according to your project needs.

Contact Us

Alfa Cytology provides the capability to measure growth factor concentrations in both peripheral blood in vivo and cell culture in vitro. Through our extensive services, we can assist in determining an appropriate starting dosage for your prospective brain tumor therapeutics. For further inquiries regarding our services, please reach out to us to discuss project specifics.

Reference

1. Golán-Cancela I., & Caja L. (2024). The TGF-β Family in Glioblastoma[J]. International journal of molecular sciences. 25(2), 1067.