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Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified)

Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified)

CAT#: IVD-P007

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Overview Specification

Species	Human
Tag	Tag Free
Expression Systems	HEK293 cell
Keywords	In vitro diagnostic proteins

Synonyms	NACP, PARK1, PARK4, PD1
Background	Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at the presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Source	Human Alpha-Synuclein (E46K)
SWISS	P37840-1
Theoretical Molecular Weight	14.5 kDa
Formulation	Supplied as 0.2 μm filtered solution in 50 mM HEPES, 100 mM NaCl, pH8.0 with trehalose as protectant.
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Molecular Characterization	This protein carries no "tag". The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	> 95% as determined by SDS-PAGE. > 90% as determined by SEC-MALS.
Storage	Please avoid repeated freeze-thaw cycles. This product is stable after storage at: The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Shipping	This product is supplied and shipped with dry ice, please inquire the shipping cost.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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