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Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

CAT#: PFF-S023

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Overview Specification

Species	Human
Tag	Tag Free
Keywords	Preformed fibrils

Synonyms	pyro abeta, pyro amyloid beta, Abeta, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, pyroglutamate amyloid beta, AβPE3, APP
Background	Our Amyloid Beta pyroglutamate 3-42 (pyro Aβ) Pre-formed Fibrils are generated from Amyloid Beta Peptide 3-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP). Our pyro Aβ3-42 fibrils present as primarily long strands when observed under TEM and AFM, and have a unique high molecular weight signal on a Western Blot with an anti-amyloid beta antibody. Amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils, and ultimately plaques. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation. Pyroglutamate Aβ 3-42 is an N-terminally truncated peptide species that is modified by glutaminyl cyclase and has been reported to compromise 15-45% of total amyloid beta deposits in the brains of AD patients. Pyroglutamate Aβ 3-42 exhibits higher aggregation propensity and neurotoxicity compared with full-length Aβ 1-42 and is an active target in the next-generation AD therapeutic development.
Description	Amyloid Beta Protein
SWISS	P05067
Gene ID	351
Cellular Localization	Cell membrane, Intracellular Vesicles
Protein Length	40 aa
Applications	WB, In vivo assay, In vitro assay
Research Areas	Alzheimer's Disease, Amyloid, Neurodegeneration, Neuroscience
Concentration	Lot/batch specific. See included datasheet.
Nature	Synthetic (TFA preparation, HFIP treated precursor)
Storage Buffer	10 mM HCl with 2% DMSO
Purity	>95%
Storage	Stored at -80°C
Shipping	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Notes	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

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