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Human APP/SAPPbeta Protein, His Tag (MALS verified)

Human APP/SAPPbeta Protein, His Tag (MALS verified)

CAT#: IVD-P002

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Overview Specification

Species	Human
Tag	His
Expression Systems	HEK293 cell
Keywords	In vitro diagnostic proteins

Synonyms	ABPP, APPI, Amyloid-beta A4 protein
Background	Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.
Source	Human SAPPbeta
SWISS	P05067-8
Theoretical Molecular Weight	73.8 kDa
Formulation	Lyophilized from 0.22 μm filtered solution in PBS, 0.3M Arginine, pH 7.4. Normally trehalose is added as protectant before lyophilization.
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Molecular Characterization	This protein carries a polyhistidine tag at the C-terminus. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	> 95% as determined by SDS-PAGE. > 90% as determined by SEC-MALS.
Storage	For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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