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Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils

Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils

CAT#: PFF-S021

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Overview Specification

Species	Human
Tag	Tag Free
Expression Systems	E.coli
Keywords	Preformed fibrils

Synonyms	Superoxide dismutase1 Protein, ALS1 Protein , SOD1 Protein, IPOA Protein
Background	Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulfide bridge. The second form (SOD2) is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however, it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space. SOD3 can also be distinguished by its heparin-binding capacity. Studies have shown that in vitro, Cu-Zn SOD (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1.
Description	SOD Protein
SWISS	P00441
Accession Number	NP_000445.1
Gene ID	6647
Cellular Localization	Cytoplasm, Mitochondrion, Nucleus
Protein Length	Full length
Applications	WB, SDS-PAGE, In vivo assay, In vitro assay
Research Areas	ALS Disease, Cancer, Cell Signaling, Chaperone Proteins, Neurodegeneration, Neuroscience, Oxidative Stress, Protein Trafficking
Concentration	Lot/batch specific. See included datasheet.
Nature	Recombinant
Storage Buffer	PB pH 7.4, 5 mM EDTA, 50 mM DTT
Purity	>95%
Purification	Ion-exchange Purified
Storage	Stored at -80°C
Shipping	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Notes	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

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