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Human S100B Protein, His Tag

Human S100B Protein, His Tag

CAT#: IVD-P021

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Overview Specification

Species	Human
Tag	His
Expression Systems	E.coli
Keywords	In vitro diagnostic proteins

Synonyms	S100B, NEF, S100, S100beta
Background	S-100 protein beta chain (S100B), a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc tightly-distinct binding sites with different affinities for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction, S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Furthermore, S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation of many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Source	Human S100B
SWISS	NP_006263
Theoretical Molecular Weight	11.5 kDa
Formulation	Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 8.0 with trehalose as protectant.
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Molecular Characterization	This protein carries a polyhistidine tag at the N-terminus. The protein migrates as 11 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	>95% as determined by SDS-PAGE.
Storage	For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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