Cancer R&D 2024 has wrapped up successfully. We’re grateful for your interest and interaction with Alfa Cytology. We’re eager to continue providing our expertise in cancer drug development. Let’s look back on these memorable moments!

Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

CAT#: PFF-S011

Inquiry

Overview Specification

Species	Human
Tag	Tag Free
Keywords	Preformed fibrils

Synonyms	Abeta Protein, Abeta peptide, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, APP, Abeta Pre-formed Fibrils Protein, Abeta Pre-formed Fibrils Protein, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, APP, Abeta Protein PFF, Abeta peptide PFF, Beta amyloid PFF
Background	In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), aggregating into oligomers, protofibrils, fibrils, and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD). Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function. Aβ oligomers generated in vitro were toxic to PC12 cells and SH-SY5Y cells. Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson’s disease patients with dementia.
Description	Amyloid Beta Protein
SWISS	P05067
Gene ID	351
Cellular Localization	Cell membrane, Intracellular Vesicles
Amino Acid Sequence	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Protein Length	42 aa
Applications	WB, SDS PAGE, In vitro assay
Research Areas	Alzheimer's Disease, Amyloid, Neurodegeneration, Neuroscience
Concentration	Lot/batch specific. See included datasheet.
Nature	Synthetic (TFA preparation)
Storage Buffer	10 mM HCl + 2% DMSO
Purity	>95%
Storage	Stored at -80°C
Shipping	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Notes	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Online Inquiry

Alfa Cytology provides its clients with one-stop solutions to accelerate therapeutic discovery and development of brain tumors.

By Disease

Craniopharyngioma

Schwannoma (neuroma)

Pituitary Tumors

Choroid Plexus Tumors

By Molecule Type

Small Molecule Drug

Therapeutic Antibody

Immune Cell Therapy

Oncolytic Virotherapy

Vaccine Development

Contact Us

Copyright © 2024 Alfa Cytology. All rights reserved.