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Human Tau-441 / 2N4R (241-380) Protein, His Tag (MALS verified)

Human Tau-441 / 2N4R (241-380) Protein, His Tag (MALS verified)

CAT#: IVD-P025

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Overview Specification

Species	Human
Tag	His
Expression Systems	E.coli
Keywords	In vitro diagnostic proteins

Synonyms	DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU
Background	Tau is a microtubule-associated protein, which is encoded by the MAPT gene located on chromosome 17q21. Tau Promotes microtubule assembly and stability and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consists of 441 amino acids. Tau-441 is a potential therapeutic target for pathogenesis.
Source	Human Tau-441
SWISS	P10636-8
Theoretical Molecular Weight	16.9 kDa
Formulation	Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH 7.5 . Normally trehalose is added as protectant before lyophilization.
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Molecular Characterization	This protein carries a polyhistidine tag at the N-terminus. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Storage	For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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