Metabolomics Analysis for Brain Tumors

Serving as a complement to genomics and proteomics, metabolomics offers a powerful tool to identify tumor biomarkers and investigate intricate metabolic reactions within the tumor microenvironment. Alfa Cytology offers sensitive and comprehensive metabolomics analysis services to examine specific metabolic signatures of brain tumors, aiming to shed more light on brain tumor biology.

Overview of Metabolomics

Metabolomics involves the systematic detection and measurement of endogenous and exogenous small molecule metabolites, including nutrients, signaling mediators and other metabolic products in blood, urine, cerebrospinal fluid and other body fluids. By delving into the dynamic metabolic process within the brain tumor microenvironment, metabolomics provides detailed insights into how cells respond to genetic variations and pathophysiological triggers during brain tumor initiation, progression and metastasis.

Fig.1 Cancer and metabolism interact at many levels. (Schmidt DR., et al., 2021)

Metabolomics for Brain Tumor Therapy Development

During brain tumor growth and progression, metabolism is dysregulated to achieve the demands of uncontrolled cell proliferation and metabolic phenotype alterations are widely acknowledged as crucial indicators for tracking brain tumor progression and evaluating potential therapy efficacy. Metabolomics enables researchers to gain a comprehensive comprehension of the intricate spatiotemporal regulatory network involving enzymes and metabolites within the dynamic brain tumor microenvironment, which aids the early diagnosis of tumors and facilitates the discovery of potential therapeutic targets.

Our Services

Tumor metabolism within the tumor microenvironment is an active area of research. Metabolomics analysis provides crucial insights into metabolic reprogramming at specific stages of tumor initiation and progression. Alfa Cytology specializes in advanced techniques such as nuclear magnetic resonance (NMR) and mass spectrometer (MS) combined with chromatography to detect alterations in metabolites across various brain tumor tissues, aiming to assist your exploration of various metabolite molecules and their functions during tumor progression.

Workflow of Metabolomics

Sample Preparation

Metabolomic Profiling

Library Construction

Data Analysis

Why Choose Us?

Metabolic reprogramming stands out as a key characteristic in the development of brain tumors, emphasizing the importance of investigating the molecular mechanisms governing brain tumor metabolism. Alfa Cytology is committed to elucidating the roles and molecular intricacies of metabolites, crucial enzymes and transporter proteins in the progression of brain tumors through our advanced metabolomics analysis. We hope to pave the way for early detection and identification of new biomarkers and novel drug targets for brain tumors. Reach out to our dedicated team to collaborate on developing a customized protocol to further your brain tumor research.

Reference

1. Schmidt DR.; et al. (2021). Metabolomics in cancer research and emerging applications in clinical oncology[J]. CA: a cancer journal for clinicians. 71(4), 333–358.