Proteomics Analysis for Brain Tumors

Cellular protein expression profiles within tissues and their spatial organization are key to understanding tumor pathology. To precisely define molecular phenotypes in the spatial context of tissues, Alfa Cytology offers cutting-edge and unbiased proteomics analysis services tailored to your brain tumor research.

Overview of Proteomics

Proteomics refers to the large-scale analysis of all proteins in an organism or cell, including the study of their abundance, expression, localization, posttranslational modifications and molecular interactions. During brain tumor growth and progression, the accumulated alterations in DNA sequencing can profoundly impact the protein landscape, where proteomics is considered a potent tool to profile functional proteins involved in brain tumor advancement and reveal the actual state of tumor cells in real time.

Fig.1 Overview of proteomics technologies in cancer liquid biopsies. (Ding Z., et al., 2022)

Applications of Proteomics in Brain Tumors

Proteomics plays a pivotal role in brain tumor research by serving as a crucial tool for identifying diagnostic and prognostic biomarkers. Moreover, it unravels the intricate complexities inherent in the brain tumor microenvironment, providing invaluable insights essential for understanding the dynamics of tumorigenesis and facilitating the development of potential therapeutics for brain tumors.

Our Services

To analyze the pathogenesis of brain tumors from a holistic perspective and find specific markers for diagnosis and prognosis of brain tumors, Alfa Cytology leverages a range of advanced technologies, including bi-directional gel electrophoresis (2D-PAGE), high-performance liquid chromatography (HPLC), laser capture microdissection (LCM), iTRAQ markers and mass spectrometry technology. These techniques are meticulously integrated to optimize our proteomics analysis services, ensuring a thorough examination of the intricate protein landscapes associated with brain tumors.

The proteomics analysis approach offered caters to the demand for highly multiplexed, quantitative, spatially resolved measurements of proteins within brain tumor tissues, encompassing a range of contents.

Protein Microarray Services for Brain Tumors

Protein microarray technology has unparalleled advantages over traditional methods such as high throughput screening, high sensitivity detection, fully automated operation and high miniaturization. Through the combination of MS technology and protein microarrays, we can simultaneously detect and analyze multiple proteins related to brain tumors and rapidly analyze protein profiles from a minimal number of brain tumor cells.

The process begins by depositing protein molecules onto a substrate in a designed array format, followed by the interaction with sample proteins labeled with fluorescence on the microarray surface. Subsequently, the fluorescence signal is scanned and analyzed using a laser confocal microscope and CCD camera to obtain precise and informative results.

Our Services Help You Achieve the Following Goals

• Offer valuable insights into the intricate molecular landscape underlying brain tumor development and progression.
• Facilitate the development of brain tumor diagnosis and prognosis.

Why Choose Us?

At Alfa Cytology, we continually integrate diverse technologies to offer advanced brain tumor proteomics and protein microarray services, enabling our clients to access groundbreaking insights into brain tumor biology. Reach out to our specialized team for tailored analytical solutions to meet your specific research needs.

Reference

1. Ding Z.; et al. (2022). Proteomics technologies for cancer liquid biopsies[J]. Molecular cancer. 21(1), 53.