| Product Information
|
It targets S100 Beta in WB, IHC, IF, ELISA applications and shows reactivity with Human, mouse, pig, rat samples. |
| Background Information
|
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs and has been implicated in the regulation of cellular activities such as metabolism, motility and proliferation. In the nervous system, S100B is constitutively released by astrocytes into the extracellular space and at nanomolar concentrations, it can promote neurite outgrowth and protect neurons against oxidative stress. Within the central nervous system (CNS), S100B is thought to be a marker for astroglial activation, linking astrocyte dysfunction to schizophrenia. In addition to astrocytes, S100B is released from many cell types, such as, adipocytes, chondrocytes, cardiomyocytes and lymphocytes. Serum S100B represents a new biomarker for mood disorders. |
| Synonyms
|
NEF, Protein S100 B, S 100 protein beta chain, S 100 protein subunit beta, S100, S100 Beta, S100 calcium binding protein B, S100B, S100beta |
| Full Name
|
S100 calcium binding protein B |
| Tested Reactivity
|
Human, mouse, pig, rat |
| Cited Reactivity
|
Human, mouse, rat |
| Type
|
Antibody |
| Class
|
Monoclonal |
| Immunogen
|
S100 Beta fusion protein |
| Calculated Molecular Weight
|
11 kDa |
| Observed Molecular Weight
|
11 kDa |
| GenBank Accession Number
|
BC001766 |
| Gene ID
|
6285 |
| Gene Symbol
|
S100B |
| Form
|
Liquid |
| Purification Method
|
Protein G purification |
| Storage Buffer
|
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions
|
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage. |
| Positive WB Detected
|
Rat brain tissue, C6 cells, pig brain tissue |
| Positive IHC Detected
|
Human malignant melanoma tissue, human appendicitis tissue, mouse brain tissue, rat brain tissue |
| Positive IF Detected
|
Rat brain tissue |
