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Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)

Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)

CAT#: PFF-S009

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Overview Specification

Species	Human
Tag	Tag Free
Expression Systems	Baculovirus (Sf9)
Keywords	Preformed fibrils

Synonyms	MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
Background	Brain-specific tau isoforms vary in the number of N-terminal inserts and C- C-terminal repeat domains due to alternative splicing of exons; the 2N4R isoform of tau is expressed in the adult brain yet is absent from the fetal brain. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as Alzheimer’s Disease (AD) are characterized by neurofibrillary tangles containing hyper-phosphorylated tau fibrils. Hyper-phosphorylated tau can be generated via expression in the Sf9/Baculovirus system, with up to 20 sites confirmed by mass spectrometry and Western Blots with phospho-specific antibodies. Sf9/Baculovirus-expressed Tau 2N4R Pre-Formed Fibrils are generated without heparin.
Description	Human Recombinant Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)
SWISS	P10636-8
Amino Acid Sequence	MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Applications	WB, SDS PAGE, In vitro assay
Research Areas	Alzheimer's Disease, Neurodegeneration, Neuroscience, Tangles & Tau
Concentration	Lot/batch specific. See included datasheet.
Nature	Recombinant
Storage Buffer	1X PBS pH 7.4
Purity	>95%
Purification	Ion-exchange Purified
Storage	Stored at -80°C
Shipping	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Notes	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

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