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Learn MoreCAT#: PFF-S007
Species | Human |
Tag | Tag Free |
Expression Systems | E.coli |
Keywords | Preformed fibrils |
Synonyms | Tau aggregate, Tau PFFs, Tau PFF, Tau protein aggregate, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, dGAE Tau Protein, Tau dGAE |
Background | Filamentous tau inclusions are a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE), collectively called tauopathies. Utilizing Tau filaments with the correct disease-specific fold is an important goal towards better mimicking specific human diseases in cellular and in vivo models. |
Description | Human Recombinant Tau dGAE (297-391) AD-mimic Pre-formed Fibrils (fibrilized without heparin) |
SWISS | P10636-8 |
Amino Acid Sequence | IKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAE |
Protein Length | Fragment of full length wild-type Tau 2N4R (297 - 391 aa) |
Applications | WB, SDS PAGE, In vitro assay |
Research Areas | Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Cytoskeleton, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Tangles & Tau |
Concentration | Lot/batch specific. See included datasheet. |
Nature | Recombinant |
Storage Buffer | 10 mM PB pH 7.4, 10 mM DTT, 200 mM MgCl2 |
Purity | >95% |
Purification | Ion-exchange Purified |
Storage | Stored at -80°C |
Shipping | Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order. |
Notes | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |