Xenograft Brain Tumor Models
Xenograft models have emerged as pivotal tools in neuro-oncology, especially for the study of glioblastoma (GBM). The ability of xenografts to mimic human tumor biology makes them indispensable for preclinical studies. At Alfa Cytology, we specialize in providing comprehensive preclinical research services, including the development and utilization of xenograft brain tumor models.
Introduction to Xenograft Brain Tumor Models
Xenograft brain tumor models are characterized by the implantation of human-derived tumor cells into immunodeficient mice, such as NOD-scid or athymic nude mice. These models facilitate the examination of tumor growth dynamics, metastatic behavior, and therapeutic efficacy in a controlled environment that closely resembles human physiology. The advantages of using xenograft models include:
Realistic Tumor Microenvironment
Xenografts maintain the heterogeneity and complexity of human tumors, offering insights into tumor-host interactions and the tumor microenvironment (TME).
Therapeutic Evaluation
These models are widely used to assess the efficacy of new drugs, radiation therapies, and immunotherapies. They provide critical data on how human tumors respond to various treatment modalities.
Genetic Manipulation
Researchers can genetically modify tumor cells to study specific oncogenic pathways, facilitating the investigation of targeted therapies.
Our Services
At Alfa Cytology, we specialize in providing comprehensive preclinical research services, including the development and utilization of xenograft brain tumor models. Our state-of-the-art facilities and expert team enable us to deliver high-quality research tailored to the specific needs of our clients.
PDX Model
Available Brain Tumor PDX Model
- GBM-PDX-1
- GBM-PDX-2
- GBM-PDX-3
- MB-PDX
CDX Model
Available Brain Tumor CDX Model
- Glioblastoma: M059J, U87MG, U251, A172, LN-229, U-118MG
- Neuroblastoma: SH-SY5Y
- Medulloblastoma: DAOY, D283
- Astrocytoma: U373
- Ependymoma: CHLA-266
Contact Us
For researchers and organizations seeking to advance their understanding of brain tumors through xenograft models, Alfa Cytology offers unparalleled expertise and resources. Our dedicated team is ready to assist you in your preclinical research endeavors. To discuss your specific needs or to learn more about our services, please feel free to contact us to customize your needs.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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