Cancer R&D 2024 has wrapped up successfully. We’re grateful for your interest and interaction with Alfa Cytology. We’re eager to continue providing our expertise in cancer drug development. Let’s look back on these memorable moments!
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Breast cancer cell line development creates and optimizes cell lines that accurately reflect breast tumors. These cell lines are crucial for studying cancer biology, testing therapies, and understanding drug resistance. They provide a consistent model for exploring treatment effects and molecular mechanisms. Alfa Cytology offers a comprehensive suite of breast cancer cell line development services tailored for research and clinical applications.
Breast cancer (BC) refers to a malignant tumor in which the breast's glandular or ductal epithelial cells become cancerous, ranking first in the incidence of female malignant tumors. Bioengineering techniques are increasingly applied to designing and constructing patient-specific models to understand the unique biological properties of BC and facilitate the research of new therapeutic targets. BC cell models are important and powerful tools for BC research. Much of what researchers know about BC is based on studies of BC cell lines in vivo and in vitro. Although there are more commonly used BC organoid models or animal models, BC cell models are still indispensable in BC research.
Breast cancer cell culture classification by morphological structure. (Witt BL, 2023)
Alfa Cytology can provide you with in vitro cell models of BC, including 2D cell lines and 3D spheroids, and we are committed to helping researchers study BC in an efficient, cost-effective, and effective manner. 2D cell culture is the easiest, fastest, and most economical format to study metastasis and invasion. Furthermore, by co-culturing cancer cells with stromal cells, 2D cell culture can be used to mimic signals from tumor microenvironment (TME) tumors and compound screening for antitumor drugs.
| BC 2D cell lines from Alfa Cytology | |
|---|---|
| luminal A | MCF-7 |
| luminal B | T47D, BT474, ZR75.1 |
| HER2+ | SKBR3, UACC-893 |
| TNBC | MDA-MB-231, MDA-MB-468, BT20, HCC38, HCC1937, HCC1806, SUM149, SUM159, SUM1315 |
The spheroid is the first 3D cancer cell model, and BC 3D spheroid model can more accurately reflect BC tumor biology and tumor microenvironment. Our modeling techniques include static approaches such as scaffold-free methods of hanging drop, liquid overlay on ultra-low attachment plates, and micropatterned plates, and dynamic approaches such as spinner flask, rotating vessels, microfluidic systems or techniques using scaffolds. We will customize the best model for you based on your needs.
Alfa Cytology is an advanced CRO company with years of experience in building BC cell models. Based on our advanced platform and experienced scientists, we can build customized, cost-effective, high-quality BC cell models for BC drug and therapy development research. If you are interested in learning more about our BC cell model services, please contact us. We will provide you with a professional and competitively priced strategy as soon as possible to meet your needs.
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