Breast Cancer Cellular Microarray Analysis
Cellular microarray analysis is a high-throughput technology that studies the expression of multiple genes or proteins simultaneously in breast cancer samples. Alfa Cytology offers a comprehensive suite of breast cancer cellular microarray analysis services.
Introduction of Cellular Microarray
Breast cancer is a highly heterogeneous disease with significant differences between patients. Microarray-based gene expression profiling can be used for BC typing to determine which treatments are most likely to produce beneficial outcomes for specific patients and to predict BC-specific biomarkers. Cellular microarray enable multiplexed analysis of living cells on a solid support surface. The support, sometimes called a "chip," is covered with different materials, such as antibodies, proteins or lipids, that interact with the cells to capture them at specific spots. Combinations of different materials can be found in a given area that, when specific interactions are present, can not only capture cells but also trigger cellular responses, phenotypic changes, or detect cellular responses. Cellular microarray increase assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a broad range of assays in drug discovery, toxicology, stem cell research, and potential therapeutics.
Fig.1 Preparation of 3D cellular microarrays. (Fernandes TG, et al., 2009)
Our Services
Alfa Cytology's cellular microarray technology identifies specific human plasma membranes and secreted proteins targeted by antibodies, proteins, small molecules, viruses, chimeric antigen receptor cells and other ligands. It provides a highly sensitive and specific platform for breast cancer cell systems biology research and drug screening.
| Services | Description |
|---|---|
| Off-target analysis cell microarray technology | Discover high-quality, exploitable drug targets and mechanisms of action and screen for potential off-target sites. |
| Target deconvolution | Accelerate phenotypic drug discovery by deconvolving targets from phenotypic molecules. |
| Off-target screening | Understand cross-reactivity, reduce toxicity-based losses and aid in lead selection. |
| Chimeric antigen receptor cell-specific screening | Safely harness the patient's own immune system by precisely identifying specific tumors. |
Cellular microarray screening provides a fast, accurate, and efficient solution for discovering BC cell surface and secreted protein targets, including antibodies, proteins, viruses, and small molecules. It can deepen our understanding of the BC process and reveal the basis of drug action mechanisms and their potential toxicity.
Advantages of Our Services
- Discover high-quality and exploitable drug targets
- Explore the safety profile of lead candidates using the most comprehensive human expression off-target system
- Determine confidence in prenatal safety and generate supporting data
Alfa Cytology boasts extensive expertise in BC research garnered over many years. We are committed to continuous innovation, perpetually exploring improved solutions for our clientele, and ensuring the delivery of top-notch products and services. If you are interested in learning more about our BC cellular microbiota analysis services, please don't hesitate to contact us. Our dedicated and knowledgeable staff will promptly get in touch with you.
Reference
- Fernandes TG, et al. High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol. 2009 Jun;27(6):342-9. .