Breast Cancer TIL Cell Therapy Development

Tumor-infiltrating lymphocyte (TIL) cell therapy is an innovative immunotherapeutic approach that harnesses the body's own immune response to target and destroy breast cancer cells. TILs are a subset of lymphocytes that have migrated into tumor tissues, where they exhibit the potential to recognize and attack cancer cells effectively. Alfa Cytology is committed to advancing TIL cell therapy development for breast cancer.

Introduction to TIL Cell Therapy

Tumor infiltrating lymphocyte (TIL) cell therapy mainly relies on the ability of lymphocytes in or near the tumor to recognize and kill tumor cells. Through in vitro isolation and expansion, it can expand the immune response and strengthen the anti-tumor effect. TIL mainly includes T cells, macrophages, NK cells, and dendritic cells. Because TIL comes from tumor tissue, it has strong tumor-homing properties and has a good targeting effect on tumor cells. As a new type of immune cell therapy, TIL therapy has shown good curative effects in a variety of cancer types, whether it is used alone or in combination with other treatment methods or drugs, it has shown ideal curative effect. Compared with other immunotherapies, TIL has the advantages of multiple targets, strong tumor tendency and infiltration ability, and small side effects, therefore, it can be used as an ideal treatment for breast cancer (BC).

Fig.1 Combination of TIL therapy with other therapies. (Zhao Y, et al., 2022)

Our Services

Alfa Cytology can provide you with BC TIL cell therapy development services. TIL has the advantages of multiple targets, strong tumor tendency and infiltration ability, and small side effects, and is an important candidate therapy for the treatment of BC solid tumors. Our services include:

• TIL isolation and culture
  We cut the tumor tissue into small pieces, and then add collagenase, deoxyribonuclease, and hyaluronidase to further digest the tumor fragments. TILs were isolated by density gradient centrifugation or specific cell sorting methods (MACS/FACS).
• TIL immunophenotyping
  Our TIL immunophenotyping service can describe the infiltration pattern, absolute cell count and density of TIL, and quickly identify the type and function of immune cells. It can help you classify tumors and translate them into the clinicopathological domain, facilitating a better description of the spatial relationship between immune cells and vasculature, tertiary lymphoid structures, and other tumor-associated histological features.
• TIL detection
  Our TIL analysis techniques mainly include immunofluorescence, immunohistochemistry, flow cytometry analysis, mass spectrometry flow cytometry, etc. We will provide you with the most suitable customized TIL analysis service according to your needs.

Advantages of TIL Cell Therapy

Alfa Cytology' team is composed of highly educated and highly qualified professionals with good professional backgrounds and BC research experience. With the introduction of immunotherapy, TIL therapy has received increasing attention from researchers. If you are interested in learning more about our BC therapy development services, please feel free to contact us. Our professional and patient staff will contact you as soon as possible.