Peptidomimetic Development for Breast Cancer

Peptidomimetics represent a promising class of therapeutic agents in the fight against breast cancer. These compounds are designed to mimic the structure and function of peptides, which are often crucial in biological signaling processes, including those that regulate tumor growth and metastasis. Alfa Cytology is dedicated to advancing the development of peptidomimetic therapies for breast cancer.

Introduction to Peptidomimetic

Peptidomimetics are compounds that simulate the three-dimensional structure and pharmacophore of peptides or proteins. They are usually produced by modifying existing peptide segments. Using peptidomimetics as therapeutics has many advantages, such as enhanced binding, improved metabolic stability, and good bioavailability. Many peptidomimetics have been found to be effective in treating a variety of cancer cell lines and multidrug-resistant cancer cells even at low doses. In human breast cancer (BC) xenograft models, cationic amphipathic peptides have a significant inhibitory effect on tumor growth. So peptidomimetics are a valuable alternative to peptides and a viable option to fight cancer cells.

Fig.1Advantages of peptidomimetics over peptides. (Lenci E, et al., 2020)

Our Services

Alfa Cytology has a self-developed peptidomimetic research platform that can provide BC-related peptidomimetic development services. Peptidomimetics are powerful tools in medicinal chemistry. Both in terms of pharmacological and pharmacokinetic properties, they are significantly improved compared to peptide drugs, and they can be delivered orally on a large scale. Services we can provide include: 

• Design of peptidomimetics
  The design strategy of peptidomimetics depends on the known structure, sequence, protein binding site and other relevant information of the target protein. Through peptide scanning technology, the shortest peptide sequence with biological effects is obtained. Likewise, alanine or D-amino acid scanning can help identify pharmacophores. Subsequently, the lead peptidomimetics were optimized using different methods to obtain drug candidates with oral bioactivity.
• Modification of peptidomimetics
  Modification of peptidomimetics can improve the affinity of peptidomimetics to receptors, enhance pharmacological stability, reduce degradation of peptidomimetics in the body, etc. Our peptidomimetics research platform can perform local modification, secondary structure simulation and overall conformation modification of peptidomimetics.
• Screening of peptidomimetic drugs
  Peptidomimetics are ideal chemical tools for treating BC, and it is important that accurate screening has identified peptidomimetics that bind with precise specificity and affinity to their targets. We can provide services such as in vivo and in vitro screening, pharmaceutical analysis, pharmacokinetic studies, and safety evaluation of peptidomimetic.

Advantages of Peptidomimetic

Alfa Cytology is a world-leading preclinical CRO company dedicated to assisting scientists around the world in BC research. We can provide you with BC-related peptidomimetic development services, giving you peace of mind and assisting project progress. If you have any questions about BC studies, please contact us and our experts will assist you as soon as possible.