Protein Vaccine Development for Breast Cancer

Unlike conventional vaccines that rely on whole pathogens, protein vaccines utilize purified proteins or peptides derived from tumor antigens to elicit a targeted immune response. This approach aims to stimulate both humoral (antibody-mediated) and cellular (T-cell mediated) immunity against breast cancer cells, enhancing the body's ability to identify and destroy malignant cells. Alfa Cytology specializes in the comprehensive development of protein vaccines for breast cancer.

Introduction to Protein Vaccine

Breast cancer has become the most commonly diagnosed cancer worldwide. Cancer vaccines are an attractive therapeutic option because they are designed to induce long-lasting immune responses to eliminate tumor cells. Protein vaccines are developed using intact or shortened fragments of tumor antigen proteins. It is capable of uptake, processing and presentation of multiple MHC class I and class II peptide epitopes and is not HLA-restricted as they contain both HLA class I and class II epitopes. Research shows that protein vaccines can induce specific immunity and are effective in the prevention and treatment of breast cancer.

Fig.1 Different types of breast cancer vaccines and their mechanisms. (Zhu SY, et al., 2022)

Our Services

Alfa Cytology, as the world's leading preclinical CRO company, provides innovative products and services, including the research, development, production, formulation and quality control of breast cancer protein vaccines. Vaccines composed of pathogen proteins, protein subunits or peptides can induce potent immune protection in the body. Our technical tools and high-quality reagents produce and purify proteins and protein subunits with the highest yield and purity. Our services mainly include the following processes:

• Gene cloning
  Clone specific protein genes into expression vectors to construct recombinant expression vectors.
• Cell culture
  Transfect the recombinant expression vector into host cells and produce recombinant proteins on a large scale through cell culture technology.
• Protein purification
  Purify recombinant proteins from cell culture fluid through centrifugation, chromatography, electrophoresis and other techniques to obtain high-purity protein vaccines.
• Vaccine preparation
  Mix the purified recombinant protein with appropriate adjuvants to prepare a vaccine. We will strictly consider factors such as vaccine source, vaccine antigen and adjuvant selection, vaccine target optimization, activity restrictions and combination therapy to provide customers with protein vaccine development services for breast cancer.
• Vaccine verification
  In vitro tests, in vivo animal tests, selection of the best regimen (dose, dosage regimen and route of administration), feasibility and immunogenicity assessment of protein vaccines, stability analysis of protein vaccines, safety and efficacy assessment of protein vaccines.

Alfa Cytology is a world-leading preclinical CRO company dedicated to assisting scientists around the world in BC research. We can provide you with BC protein vaccine development services and help in the treatment and diagnosis of BC. If you have any questions about BC research, please contact us and our experts will get back to you as soon as possible.