The most important feature of spontaneous breast cancer (BC) tumor models is that it occurs naturally in experimental animals without artificial treatment, and its etiology is similar to that of humans. Therefore, animal models of spontaneous BC are often used to study the etiology and treatment of BC. The induced mammary gland tumor model is artificially using chemical, physical and biological carcinogens to treat animals through oral administration, injection, systemic therapy, etc., to induce the rapid occurrence of mammary gland tumors. This model has a high incidence rate, a short incubation period, and reliable prediction results. It is often used to study the etiology and prevention of BC.
Fig. 1. Biological approach to induce breast tumors. (Zeng L, et al., 2020)
Tumor animal models play a vital role in basic research on tumor occurrence, development, and metastasis, as well as drug development and treatment. Therefore, tumor research is inseparable from the establishment of animal models. Alfa Cytology can provide you with spontaneous and induced breast tumor mouse models.
Our animal models of spontaneous breast tumors are mainly from inbred mice.
We can provide you with induced breast tumors animal models through chemical, physical and biological carcinogens.
We use 7,12-dimethylbenzo(a)anthracene, 3,4-benzopyrene, 3-methylcholan-threne (MCA), N-methyl-N-nitrosourea (MNU), 2-acetylamino-fluorene, 3,4-benzopyrene, and urethane etc. to induce breast tumors.
We induce breast tumors by ionizing radiation, which typically induces hormone-dependent adenocarcinomas or fibroadenomas.
We biologically induced breast tumors by lentivirus overexpression of oncogenes or silencing of tumor suppressor genes in experimental animals.
Alfa Cytology' BC spontaneous and induced tumor animal models have very important theoretical value and clinical significance in the study of BC pathogenesis, discovery of new drug targets, treatment, prevention, and efficacy evaluation. We have many years of experience in establishing BC models, including BC animal models, BC cell models, and BC organoids. We are a leading global life sciences company that can provide custom breast tumor models according to your needs. If you are interested in our services, please contact us. Our professionalism and competitive price will be the reason for you to choose us.
Reference