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At Alfa Cytology, we understand that the complex metabolic landscape of cancer cells holds the key to unlocking groundbreaking advancements in cancer research and therapy development. We offer a comprehensive suite of services to analyze the multifaceted aspects of cancer metabolism.
Fig.1 Metabolic and signalling pathways supporting
tumour biomass production.
(Martínez-Reyes, I., & Chandel, N. S., 2021)
Cancer cells, unlike their healthy counterparts, have evolved to prioritize biomass production and rapid proliferation over efficient energy generation. This metabolic shift is fueled by the accumulation of genetic and epigenetic alterations that allow transformed cells to maintain a perpetual pro-anabolic state, even in the face of dwindling nutrient resources in the tumor microenvironment.
As cancer cells deplete the local tissue of essential nutrients, they employ a diverse array of metabolic adaptations to sustain their growth. These include the scavenging of extracellular macromolecules, the remodeling of nitrogen metabolism to prioritize nucleotide and non-essential amino acid synthesis, and the utilization of alternative carbon sources for energy and biosynthesis.
Interestingly, the metabolic byproducts generated by these adaptations can also act as signaling modulators, influencing gene expression, epigenetics, and the behavior of non-transformed cells in the tumor vicinity. Furthermore, as tumors grow and metastasize, they can profoundly impact the metabolic economy of the entire organism.
At Alfa Cytology, we recognize the crucial importance of understanding the metabolic underpinnings of cancer. Our team of expert researchers and state-of-the-art facilities are dedicated to unraveling the complexities of cancer metabolism, providing our clients with invaluable insights that can inform the development of novel therapeutic strategies. Our services include, but are not limited to:
Cancer Lipid Metabolism Analysis
Cancer Glycolytic Metabolism Analysis
Cancer Amino Acid Metabolism Analysis
Cancer Redox Metabolism Analysis
Cancer Iron Metabolism Analysis
Cancer Metabolic Symbiosis Analysis
Cancer Metabolic Crosstalk Analysis
And More
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The hallmarks of cancer metabolism are constantly evolving, and Alfa Cytology is dedicated to staying at the forefront of this dynamic field. By leveraging our expertise, cutting-edge technologies, and collaborative spirit, we are poised to uncover the next generation of breakthroughs in cancer metabolism research, ultimately contributing to the development of more effective cancer therapies. If you are interested in our service, please contact us for more details.
Reference
For research use only.