Cell expansion is an important operation in the production of cellular therapies because a single course of cellular therapy may require hundreds of millions to tens of billions of cells. Alfa Cytology offers customized cell expansion solutions designed for specific therapeutic targets and experiments to ensure that your project requirements are met precisely and efficiently.
The Role of Cell Expansion in Cell Therapy Development
Cell expansion is a critical step in the development of effective cell-based therapies, which involves culturing cells under controlled laboratory conditions to obtain the required number of therapeutic cells for an effective therapy. Expansion techniques allow researchers to grow large numbers of tumor-specific immune cells, including T cells, natural killer (NK) cells, and dendritic cells. Common methods of cell expansion include the use of growth factors, cytokines, and co-stimulatory molecules to stimulate cell proliferation, as well as large-scale expansion using bioreactor systems and microcarrier cultures. At this stage, research hotspots targeting this area include the development of serum-free media, optimization of culture conditions to preserve cell phenotype and function, to simplify production.
Fig.1 Biomaterials for antigen-specific T cell expansion for cancer immunotherapy. (Isser, A., et al., 2021)
Our Services
To meet the diverse research needs of our clients, Alfa Cytology offers expansion services for a wide range of cell types. Our experienced scientists work closely with clients and customize scalable solutions to maximize cell yields. Browse our state-of-the-art cell expansion facilities and rigorous quality control methods, which ensure optimal growth conditions are maintained throughout the expansion process
Bioreactor System
We utilize a state-of-the-art bioreactor platform for large-scale cell expansion that allows us to precisely control environmental conditions such as temperature, pH, and nutrient availability. This allows for continuous and reproducible expansion of cell populations.
Closed Culture System
To ensure the sterility and safety of the cell expansion process, we utilize closed-system culture technology. These systems minimize the risk of contamination while maximizing cell yield and viability to meet the stringent requirements of therapeutic applications.
Microfluidic Devices
We utilize microfluidic devices that allow precise manipulation of cell cultures at the microscale level. This technology facilitates high-throughput screening and optimization of expansion conditions, accelerating the development of innovative cancer therapies.
Automation and Robotics
Automation and robotics are utilized to optimize process performance, streamline cell expansion workflows, increase efficiency and scalability, and minimize human intervention.
To meet the diverse research needs of our clients in cellular therapies, our platform offers expansion services for a wide range of cell types, including immune cells, stem cells, mesenchymal stem cells (MSCs), and genetically modified cells. Alfa Cytology makes effective use of automated technology, coupled with functionally closed systems and high-quality reagents, to help rapidly obtain the targeted number of cells and to ensure optimal cell activity and function. activity and function. If you are interested in our services, please contact us as soon as possible.
Reference
- Isser, A., et al.; (2021). Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy. Biomaterials, 268, 120584.
! For research use only.
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