Dendritic Cell Based Assays
Harnessing the power of dendritic cells (DCs) in cancer immunotherapy requires accurate and reliable assays to evaluate their activation, cytokine profiles, and overall functionality. Alfa Cytology offers a wide range of services tailored to the evaluation of dendritic cell activation and cytokine profiles.
Introduction to Dendritic Cell Based Assays
- Understanding Tumor Immunity and Tolerance
Dendritic cells act as mediators between the innate and adaptive immune systems, playing a crucial role in both immune activation and immune tolerance. By studying the intricate interactions between dendritic cells and tumor cells, researchers gain a deeper understanding of the mechanisms governing tumor immunity and tolerance.
- Assessing Immunotherapeutic Strategies
Dendritic cell-based assays can assess the ability of dendritic cells to present tumor antigens, activate cytotoxic T cells, and induce long-lasting antitumor immune responses. Such evaluations aid in the development and optimization of novel immunotherapies.
Fig.1 Regulation of DC function by tumours. (Wculek, S. K., et al., 2020)
Our Services
At Alfa Cytology, we offer a comprehensive range of dendritic cell-based assays tailored to meet the diverse needs of our clients in the pharmaceutical and biotechnology industries. Our services include, but are not limited to:
Dendritic Cell Isolation and Characterization
Our experienced team utilizes optimized protocols to ensure the purity and viability of isolated DC populations. Through flow cytometry and functional assays, we comprehensively characterize these cells, assessing their phenotype, maturation status, and antigen-presenting capabilities.
Antigen Presentation Assays
We offer a range of antigen presentation assays that allow for the evaluation of DC-mediated immune activation. Our assays include both in vitro and in vivo models, enabling the assessment of various aspects of antigen presentation, such as cross-presentation, cytokine production, and T cell priming.
Cell Interactions and Co-culture Assays
By employing imaging techniques, molecular profiling, and functional assays, we decipher the intricate cross-talk, facilitating a comprehensive understanding of immune regulation and immunomodulatory interventions.
By assessing the activation requirements and cytokine profiles of dendritic cells, these assays provide crucial insights into the immunomodulatory potential of novel therapeutic agents. Alfa Cytology offers comprehensive services in dendritic cell-based assays, enabling accurate and predictive evaluation of immunotherapies. If you are interested in our service, please contact us for more details.
Reference
- Wculek, S. K., et al.; (2020). Dendritic cells in cancer immunology and immunotherapy. Nature Reviews Immunology, 20(1), 7-24.
For research use only.
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