Epigenomics Services for Cancer Research
Epigenomics offers comprehensive tools to map and understand the epigenetic modifications that play a crucial role in cancer development and progression. At Alfa Cytology, we offer a wide range of services to support researchers in unraveling the complexities of cancer epigenetics.
Overview of Cancer Epigenomics
Epigenomics plays a crucial role in understanding the complex mechanisms underlying cancer. Epigenetic alterations, such as DNA methylation, histone modifications, and non-coding RNA expression, contribute to gene expression dysregulation and can serve as potential biomarkers for cancer diagnosis, prognosis, and therapeutic targets. With the rapidly evolving field of epigenomics, there is a growing need for comprehensive and reliable services to explore the epigenetic landscape of cancer.
Fig.1 Epigenetic modifications include A. DNA methylation; B; histone modification and C: Non-coding RNA. (Babar Q, Saeed A, et al., 2022)
Our Services
At Alfa Cytology, we provide state-of-the-art services tailored to your specific needs. Our team of experts is equipped with the latest technologies and analytical tools to unravel the epigenetic modifications associated with different types of cancer.
By decoding the epigenome, we aim to shed light on the underlying molecular mechanisms, identify novel therapeutic targets, and pave the way for personalized cancer therapies. Our services include, but are not limited to:
DNA Methylation Analysis
We use bisulfite sequencing and arrays to profile DNA methylation patterns across the genome, which are critical for understanding gene expression regulation in cancer.
Histone Modification Profiling
Through ChIP-seq (Chromatin Immunoprecipitation Sequencing), we analyze histone modifications that regulate DNA accessibility and chromatin structure.
ATAC-seq
By utilizing ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing), we provide insight into chromatin accessibility and can identify regulatory elements that contribute to cancer.
Chromatin Conformation Studies
We employ techniques like Hi-C to study the 3D architecture of genomes and understand the higher-order chromatin interactions in cancer cells.
Workflow of Our Services
Sample Collection and Preparation
We provide guidance on sample collection, storage, and preparation protocols to ensure high-quality epigenomic data.
Data Analysis and Interpretation
Our bioinformatics experts analyze the epigenomic data, employing advanced algorithms and tools to identify key epigenetic alterations.
Epigenomic Profiling
Leveraging cutting-edge technologies, we perform comprehensive epigenetic profiling of your samples, generating high-resolution data.
Results and Reporting
We provide clear and concise reports, summarizing the findings and their implications for your research.
Through our advanced technologies, expertise, and comprehensive data analysis, we enable researchers to explore chromatin accessibility, interactions, DNA modifications, and protein-DNA interactions, uncovering key epigenetic drivers and potential therapeutic targets. With Alfa Cytology as your trusted partner, you can accelerate your cancer research and contribute to improving patient outcomes. If you are interested in our service, please contact us for more details.
Reference
- Babar, Q., et al.; (2022). Novel epigenetic therapeutic strategies and targets in cancer. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1868(12), 166552.
For research use only.
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