Genetic Factors in Tumorigenesis Analysis

Tumorigenesis is a multi-step process driven by genetic mutations that can either be inherited or acquired during an individual's lifetime. These genetic changes can disrupt critical cellular pathways, leading to uncontrolled cell growth, invasion, and metastasis. Alfa Cytology is dedicated to investigating these genetic factors to identify key drivers of cancer and potential therapeutic targets.

Introduction

Tumorigenesis, also known as carcinogenesis, is the formation of cancer in which normal cells transform into cancer cells. The genetic background of tumorigenesis includes single-gene inheritance and polygenic inheritance. Due to the complex genetic basis, its genetic mechanism is still unclear. The current research on tumorigenesis mainly includes three aspects: 1. The genetic background of the susceptibility to malignant tumors. 2. The relationship between changes in genetic material or abnormal expression of genetic information and the occurrence of malignant tumors. 3. To analyze the factors that lead to the occurrence of malignant tumors in the tumor microenvironment by genetic methods. The study of genetic changes in tumorigenesis can not only provide theoretical basis for the occurrence of tumors, but also provide clues for the diagnosis and prevention of tumors.

Our Services

So far, the genetic mechanism of tumorigenesis has been related to many hypotheses, such as genetic mutation inheritance and epigenetics, chromosomal imbalance, genome instability, DNA damage, double mutation hypothesis, transforming gene hypothesis, oncogene hypothesis. However, there are still uncertainties for these studies, including the origin of cancer cells and the mechanism of carcinogenesis. At the same time, research strategies still face many challenges. Alfa Cytology is developing various technologies to explore and solve the above problems, revealing the genetic changes that cause tumors, hoping to break through the bottleneck of research and provide methods or medication guidance for clinical diagnosis, treatment and prevention of tumors.

Key Technologies

Single-cell omics techniques. During the occurrence and development of tumor cells, they interact with the tumor microenvironment, and their own genes, gene expression, and metabolism will undergo great changes. Single-cell multi-omics technology integrates multiple data models, which can provide massive information of different dimensions for the study of tumorigenesis, and provide an important basis for a comprehensive understanding of the genetic factors in tumorigenesis.

Combined application of chromosomal CGH, array-CGH, real-time PCR, microsatellite PCR and multi-target multi-color FISH technology to discover and identify tumor amplification, deletion and loss of heterozygosity genes. Combined with array-CGH detection, transcriptome sequencing, multi-target multi-color FISH and PCR analysis, the breakage, truncation and rearrangement of tumor genes were found and identified.

Alfa Cytology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.

For research use only.