Immuno-Oncology Pharmacodynamic Model Development Services
Alfa Cytology provides comprehensive, scientifically rigorous immuno-oncology pharmacodynamic model development services designed to mimic the human immune response to cancer, thereby facilitating the development of novel immunotherapies.
Overview of Immuno-Oncology Pharmacodynamic Model
Immuno-Oncology Pharmacodynamic Model is a mathematical model used to study and understand the effects of immune-based cancer therapies on the immune system and tumor cells. They allow researchers to observe the temporal dynamics of immune cell infiltration, cytokine production, and tumor regression or progression. In preclinical cancer research, immuno-oncology pharmacodynamic models are utilized to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of new drugs, and helps researchers predict how a drug will interact with the immune system and tumor microenvironment, allowing for more precise dosing and treatment strategies.
Fig.1 Evaluation of mathematical models which describe tumor vs. immune system interactions. (Peskov, K., et al., 2019)
Key Characteristics of Immuno-Oncology Pharmacodynamic Model
The immuno-oncology pharmacodynamic model encompasses several key characteristics:
- Complexity and Realism. These models incorporate multiple immune cell types, cytokines, and other components of the tumor microenvironment to closely mimic the human immune response.
- Versatility. They are applicable across various cancer types and can be customized to study specific immune interactions, such as checkpoint inhibition, T-cell activation, and the role of myeloid-derived suppressor cells (MDSCs).
- Predictive Value. By replicating the human tumor-immune system interaction, these models provide highly predictive data regarding the potential success of therapeutic interventions in clinical settings.
Our Services
With a well-established technology platform of the tumor microenvironment center, Alfa Cytology provides our clients with one-stop solutions for pretreated PDX model development. Our team of expert scientists can tailor the perfect preclinical efficacy testing strategy for your specific research needs.
Immuno-Oncology Pharmacodynamic Models Available
Alfa Cytology can provide specialized immuno-oncology pharmacodynamic models for various cancer types, including but not limited to:
|
Cancer Types |
Models Available |
Application Characteristics |
| Melanoma |
Syngeneic mouse models |
Use murine melanoma cell lines to study immune therapies in immunocompetent hosts. |
| Humanized mouse models |
Incorporate human immune cells in mice with human melanoma tumors for evaluating human-specific therapies. |
| Breast cancer |
Orthotopic breast cancer models |
Implant tumor cells into the mammary fat pad to replicate breast cancer environments. |
| Transgenic mouse models |
Genetically engineered mice develop spontaneous breast cancer for long-term studies. |
| Colorectal cancer |
Syngeneic colorectal cancer models |
Employ murine cell lines to test immune therapies in a relevant context. |
| Patient-derived xenograft models |
Transplant human colorectal tumors into mice to maintain original tumor characteristics. |
We also offer transgenic T-cell transfer models (include OT-I and OT-II T cell receptor transgenic models), which are transgenic models used to assess the regulatory function of specific T-cells in vivo, to help you evaluate whether your innovative immunotherapy can enhance the immune response.
Additionally, we will continue to introduce more tumor-related models, please contact us for more model customization services.
Our Service Process
Develop project plans based on research objectives, including model selection, experimental design, and timelines.
Consultation and Project Design
Evaluate key pharmacodynamic endpoints of therapeutic candidates using established models and analyze to identify predictive biomarkers.
Pharmacodynamic Assessment
Model Development and Validation
Build immuno-oncology models using validated cell lines or tumor samples and validate their relevance and accuracy.
Data Analysis and Reporting
Analyze experimental results and provide detailed reports including statistical analyses, visual data representations, and expert interpretations.
Alfa Cytology provides comprehensive solutions to address key challenges encountered in the field of cancer therapy development. With extensive experience in a wide range of cancer models and expertise in tumors and microenvironments, we are committed to providing our clients with the most accurate in vivo cancer models to meet the precise needs. For inquiries or to learn more about how we can support your cancer research program, please contact us.
Reference
- Peskov, K., et al.; (2019). Quantitative mechanistic modeling in support of pharmacological therapeutics development in immuno-oncology. Frontiers in immunology, 10, 450826.
For research use only.
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