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In vitro ADME for Cancer Therapy
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In vitro ADME for Cancer Therapy

ADME encapsulates the journey of a drug post-administration. In drug development, ADME involves a series of assessments to evaluate absorption, distribution, metabolism, and excretion (ADME). Alfa Cytology, a well-known provider of cancer-related services, conducts comprehensive in vitro ADME evaluations specifically for cancer therapy. We deliver accurate and reliable ADME data to support the advancement and innovation of cancer therapies.

Introduction to ADME

Introduction to the concept of ADME in pharmacokinetics and related concepts of toxicity.Fig.1 Understanding ADME in Drug Pharmacokinetics.

ADME refers to the absorption, distribution, metabolism, and excretion of drugs within the body. These processes determine the drug's concentration and duration of action, influencing its therapeutic effectiveness and potential toxicity. Researchers often use in vitro models to simulate in vivo drug behavior during ADME studies. These models may include cell cultures, tissue slices, and isolated organs. Through these methods, scientists can analyze drug absorption rates, tissue distribution, metabolic pathways, and excretion processes.

Our Services

ADME aims to characterize the actions of therapies within the human body. Alfa Cytology, dedicated to excellence, supports researchers and developers in predicting and selecting cancer therapy with optimal bioavailability and safety. Alfa Cytology offers a wide range of ADME in vitro study protocols that provide initial insights into the behavior of therapy in vivo, providing a valuable reference for drug development and research efforts.

In Vitro Assays Services

Absorption

  • Caco-2 Cell Assay System
  • Parallel Artificial Membrane Permeability Assay
  • MDCK Cell Permeability Assay

Distribution

  • Plasma Protein Binding Assays
  • Cellular Distribution Studies
  • Microsomal Distribution Assays
  • Brain Microvascular Endothelial Cell Assay System

Metabolism

  • Liver Microsome System
  • Hepatocyte Assay System
  • Cytochrome P450 Enzyme Assays
  • Recombinant Enzyme Assay System

Excretion

  • Renal Tubule Cell Assay System
  • Biliary Excretion Assays
  • Transporter Assays
  • In Vitro Dialysis Assays

At Alfa Cytology, our focus is on enhancing cancer pharmacology. We specialize in exploring the complexities of cancer pharmacology and offer comprehensive protocols for in vitro ADME studies tailored for cancer therapy. These protocols aim to enhance various facets of cancer therapy efficacy and safety. If you're interested in leveraging our expertise, please don't hesitate to contact us for more information.

For research use only.