ALL Models Development Services

Due to the diverse subtypes of acute lymphoblastic leukemia (ALL) and their distinct pathogenesis, it is crucial to develop specific animal models corresponding to each subtype for comprehensive research. Alfa Cytology offers a customized model service to effectively address this requirement. Our animal models facilitate a deeper understanding of ALL pathogenesis and provide valuable support in the discovery and evaluation of potential therapeutic drugs and novel therapeutic targets.

Introduction to ALL Models

ALL is a prevalent condition among children, characterized by abnormal proliferation of lymphoblasts. With the advent of new drugs and treatments, the overall cure rate for ALL has reached close to 90%. The utilization of ALL models plays a crucial role in drug development, as it enables the simulation of the human tumor microenvironment, evaluation of drug efficacy, and investigation of the underlying pathogenesis. Various ALL system models, including syngeneic and xenograft models, are employed for research purposes, with mice being commonly chosen as model organisms due to their genetic and hematopoietic similarities to humans. The construction of ALL animal models holds great promise in advancing the development and treatment of leukemia.

Fig. 1. Major strategies for establishing animal models of ALL. (Xin, Q. et al., 2022)

Animal models provide us with an excellent tool to understand the complex pathological mechanisms of human disease, to evaluate the potential of new targeted drugs and therapies to treat ALL in vivo, and more importantly, to assess the potential adverse drug effects they may have on healthy organs. Alfa Cytology provides various animal model development services for ALL, including but not limited to the following.

Spontaneous ALL Animal Models

Although there are few applications of spontaneous models, we can also provide customers with ALL spontaneous model construction and screening services through AKR mice to explore the mechanism of tumor occurrence.

Induced ALL Animal Models

Transgenic ALL Animal Models

Through the utilization of CRISPR-Cas9 technology, we specialize in the establishment of transgenic animal models. These models enable us to identify specific drug targets for leukemia and enhance treatment strategies for the disease. Our services encompass a range of ALL model builds, including but not limited to the following:

Xenograft Models of ALL

We offer xenograft model construction services by utilizing cells or tissues obtained from patients with ALL. Through the transplantation of B or T-cell ALL cells from these patients into immunodeficient animals, we induce the development of ALL and generate reliable ALL animal models to support research and experimentation.

Customization of ALL Models in Other Species

We provide a comprehensive selection of animal models for ALL, encompassing mice, rats, zebrafish, fruit flies, and guinea pigs. These diverse animal models can be utilized to meet the specific research needs and objectives of our clients.

Advantages of Our Services

• With our extensive experience in constructing ALL models, we boast an exceptionally high success rate.
• We have the capability to provide you with the specific ALL subtype animal model you desire.
• We are proficient in building ALL models across a diverse range of animal species, ensuring flexibility and suitability for your research needs.

Alfa Cytology provides ALL animal model design, construction, and screening services. Our goal is to provide customers with professional, high-quality ALL animal models. The animal models we provide will help you develop new therapeutic drugs to support the study of your pathogenesis. Please contact us if you need more information about our services in ALL animal models.