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A study of the genetic material of leukemia revealed chromosomal translocations in it. The analysis of gene structure is helpful to increase the understanding of the biological mechanism behind the pathogenesis of leukemia and promote the development of diagnostic methods for leukemia. Alfa Cytology can provide you with chromosomal translocation analysis for leukemia. Using advanced technologies such as FISH and NGS, we provide you with high-quality analytical services to support your research into the pathogenesis of leukemia.
Chromosomal translocation often happens in the development of leukemia, it is the molecular mechanism of leukemia occurrence and is also used as a biomarker for various hematologic malignancies. Chromosomal translocations involve the exchange of genetic material between non-homologous chromosomes, leading to the fusion of genes and the generation of novel fusion proteins. These fusion proteins can disrupt critical cellular processes, including cell proliferation, differentiation, and apoptosis, ultimately contributing to leukemogenesis. For example, chromosomal occurs between chromosomes 8q22 and 21q22 and can lead to leukemia. Chromosomal translocation is important for diagnosing, targeting therapy, predicting, and monitoring leukemia.
Fig. 1. The 8;21 chromosomal translocation. (Peterson, L.F. et al., 2007)
Alfa Cytology provides comprehensive chromosomal translocations detection development services for leukemia, including but not limited to the following.
To provide our services, we utilize the Giemsa dye for the visualization of chromosomal translocations in the standard karyotype analysis of leukemia. By carefully observing chromosome behavior during cell division, we can identify phenomena such as chromosome breakage, rearrangement, and translocation.
As part of our comprehensive services, we offer RT-PCR analysis to detect fusion genes associated with leukemia. Through our advanced genetic testing techniques, we have the capability to accurately detect and identify specific gene rearrangement events resulting from chromosomal translocations.
We can offer you the FISH analysis technique, which uses specific fluorescent probes to observe and locate chromosomal translocations. These probes can bind to specific sequences to provide visual information on chromosomal translocations. We also provide spectral karyotype analysis technology to further deepen the study of chromosome translocations in leukemia.
We utilize Giemsa staining for G-banding technology. This technique enhances the visualization and detailed analysis of chromosomes, allowing us to provide relevant and valuable information regarding chromosomal translocations in leukemia.
Leveraging next-generation sequencing technology, our whole genome sequencing service offers a more comprehensive understanding of chromosomal translocations. By sequencing the entire genome, we can detect and identify global changes associated with chromosomal translocations, enabling us to determine the specific locations and impacts of these events.
We offer nanopore sequencing as part of our services. Nanopore sequencing enables us to successfully identify the exact location of chromosomal breakpoints, yielding efficient, accurate, and comprehensive experimental results. This cutting-edge technology empowers us to provide clients with precise insights into the structural alterations caused by chromosomal translocations in leukemia.
Alfa Cytology is committed to the field of hematologic oncology, especially leukemia research. The chromosomal translocation detection technology we provide can be applied to the study of blood tumors to analyze the loci information in the genetic variation, which can bring efficient, fast, and accessible solutions to customers. If you would like to know more about our services, please contact us.
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