CML Models Development Services

In order to elucidate the molecular pathology of chronic myeloid leukemia (CML) and to develop and improve treatments, various CML models have been produced. The advent of gene editing technology has significantly enhanced the construction methods for CML models. Alfa Cytology offers animal models specifically designed for CML research, enabling in-depth studies on CML development, disease mechanisms, and treatment strategies. The CML model that we provide ensures that your experiments will yield optimal results.

Introduction to CML Models

CML is a chronic myeloproliferative tumor that accounts for about 15% of adult-diagnosed leukemia cases. The CML model is helpful in revealing the pathogenesis of CML, the mechanism of drug resistance and the development of new therapies. A variety of in vivo models have been established so far to develop and improve treatments for the molecular mechanism of cml. These models include transgenic model, xenotransplantation model and humanized model. With the development of immunodeficient xenotransplantation models, it has become possible to use cells from CML patients for in vivo research.

Fig. 1 CML human and murine models to date. Fig. 1. CML human and murine models till date. (Sontakke, P. et al., 2016)

Our Services

To reveal the molecular pathology of chronic myeloid leukemia and to develop and improve therapies, Alfa Cytology provides various animal model development services for CML, including but not limited to the following.

Conventional Transgenic Models of CML	By introducing the synthetic BCR-ABL gene into our animal model, we have successfully developed a transgenic model expressing the BCR-ABL fusion protein. This model proves invaluable in studying the pathogenic mechanisms of CML and provides crucial insights for drug development.
Conditional Transgenic CML Models	We provide conditional transgenic CML animal models. This model is a transgenic animal model with BCR-ABL under the control of the tetracycline response element (TRE). BCR-ABL1 is expressed after tetracycline withdrawal.
Retroviral Transduction Models of CML	We provide a retroviral transduction model of CML. Animals were infected with retroviruses expressing BCR-ABL1 to produce a model very similar to CML.
Xenograft Models of CML	By transplanting CML patient samples into immunodeficient animals, we offer an animal model specifically tailored for CML research, facilitating your study of CML. Additionally, we provide models that accurately simulate various stages of CML progression. Furthermore, we offer original patient samples and cell lines derived from CML patients at different stages, further enhancing the versatility of our research models.
Humanized Mice Models of CML	We provide a humanized CML animal model to solve the problem of transplant failure and simulate the human immune environment. Humanized mouse models are powerful tools for studying leukemia and can provide an appropriate microenvironment for research purposes.

Advantages of Our Services

We specialize in providing services for customizing CML models according to your specific research needs.
With our extensive experience, we excel at constructing a wide range of CML models, ensuring flexibility and diversity in your research options.
Our services include providing a model with a CML phenotype, guaranteeing the rigor and relevance of your experiments.

Alfa Cytology offers comprehensive CML animal model services aimed at investigating the interplay between leukemic cells and their microenvironment, as well as the pathogenesis of CML. Our services accelerate the study of the molecular mechanisms underlying CML pathogenesis and facilitate the development of novel targeted therapies. Please contact us if you have any questions or need more information about our services.

Reference

Sontakke, P.; et al. Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models. Stem Cells Int. 2016, 2016: 1625015.

For research use only. Not intended for any clinical use.