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Alfa Cytology offers development services for leukemia CTLA-4 inhibitors, accelerating the discovery of novel therapeutic drugs. Our services encompass drug discovery to preclinical testing, tailored to your specific project needs. Additionally, we evaluate the efficacy of CTLA-4 blockade in combination with other drugs for leukemia therapy.
CTLA-4, expressed on activated CD4+ and CD8+ T lymphocytes, as well as CD4-CD25+ regulatory T lymphocytes (Tregs), serves as an adverse prognostic factor in aggressive ATLL. Assessing immune checkpoint inhibitors' efficacy is crucial to counter the negative effects of inhibitory checkpoints. Encouraging outcomes with ipilimumab, a CTLA-4 inhibitor, have been observed in high-risk AML and MDS patients, including those who relapsed after allo-HSCT.
Fig. 1. Putative mechanisms of immune checkpoint inhibitor–associated hematologic toxicities. (Kroll, M.H. et al., 2022)
CTLA-4, a key regulator of T-cell activation and immune tolerance. Alfa Cytology's goal is to develop multiple types of molecules that regulate the CTLA-4 pathway, including but not limited to the following.
ICIs Against
CTLA-4
We assist clients in the development of a gene expression inhibitor targeting CTLA-4 for leukemia therapy. Our approach involves the screening of a diverse library of unnatural indole alkaloid-type compounds derived from enhanced extracts.
ICIs Against
CTLA-4 and PD-L1
In addition to providing development services for the CTLA-4 gene expression inhibitor, we also offer development of dual immune checkpoint inhibitors targeting PD-L1 and CTLA-4. This is achieved through the introduction of substituents and functional group transformations.
Anti-CTLA-4 Monoclonal Antibodies
For the hot topic of developing mAb-based immune checkpoint inhibitors, we offer customized services for the discovery and development of anti-CTLA-4 monoclonal antibodies. Our drug development services for leukemia can support you in discovering new effective drugs for leukemia therapy.
To address the limitations of monoclonal antibody immunotherapy, we offer development services for anti-CTLA-4 antibodies. Our approach utilizes phage display technology to screen high-quality anti-CTLA-4 antibodies from a camel immune library. Subsequently, the CDR3 region is categorized based on amino acid sequences. These antibodies demonstrate the ability to target unique epitopes on CTLA-4.
| Combination Therapy with CTLA-4 Inhibitors and PD-L1 or PD-1 Inhibitors | CAR-T Cell-based Antibodies to Block CTLA-4 |
|---|---|
| We can evaluate the efficacy of combining CTLA-4 inhibitors with PD-L1 or PD-1 inhibitors in leukemia and provide precise and dependable experimental data for your research. Our full range of services will help you discover new therapeutics for leukemia. | In the therapy of leukemia, the use of CTLA-4 inhibitors alone has shown limited promising results. We offer development services for the combination therapy of CAR-T cells with CTLA-4 inhibitors to enhance the therapeutic efficacy of CAR-T cells in leukemia. |
Alfa Cytology offers comprehensive CTLA-4 inhibitors discovery and solution services. Our dedicated team is ready to discuss your project and provide tailored solutions to accelerate your research and drug development efforts for leukemia. Contact us today to learn more about our CTLA-4 Inhibitors Development Services and how we can assist you in achieving your scientific goals.
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