γδ T Cell Therapy Development for Leukemia
γδ T cells differ from the classic and more well-known CD4+ helper T cells and CD8+ cytotoxic T cells. Generally speaking, γδ T cells are enriched in epithelial and mucosal tissues. They are considered the first line of defense against pathogen attacks. As a leading CRO company in the leukemia cell therapy field, Alfa Cytology provides a range of γδ T cell-related development services.
Introduction to γδ T Cell
γδ T cells are a special subset of T cells that play a crucial role in immune surveillance and defense against various diseases. These unique immune cells possess adaptive and innate immune characteristics, enabling them to exhibit effective cytotoxicity and produce a variety of cytokines. Therefore, γδ T cell therapy, as a promising immunotherapy method, can be used to treat cancer such as leukemia.
Fig. 1. The Results of Different Substances Regulating Gamma Delta T Cells. (Yazdanifar, M.; et al., 2020)
It is worth emphasizing that, based on existing data, the γδ T cell strategy is combined with drugs that can better target these cells to combat tumors as an alternative axis to several established therapies. Therefore, several studies have been registered aimed at optimizing the anti-tumor response of γδ T cells through genetic engineering methods.
| Interventions | Phase | Disease |
|---|---|---|
| Anti-CD19 CAR γδ T cells infusion | 1 | AcutemLymphocytic Leukemia (ALL) |
| γδ T cells infusion | 1 | Chronic lymphocytic leukemia (CLL) |
γδ T-cell therapy has become a promising immunotherapy method for treating leukemia. As the demand for this innovative therapy continues to grow, Alfa Cytology provides basic services for the development and evaluation of γδ T cell therapies, promoting the transformation of γδ T cell therapies from laboratory to clinical practice.
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γδ T Cell Isolation, Activation, and Expansion
Various techniques such as density gradient centrifugation or magnetic cell sorting are used to separate and purify γδ T cells. Stimulate isolated γδ T cells with specific compounds or antibodies to enhance their cytotoxic potential and cytokine production. Finally, use an appropriate culture medium with added cytokines to amplify activated γδ T cells. Alfa Cytology offers an advanced bioreactor system and optimized cell culture plan.
γδ T Cell Customization
Use the following genetic technology to customize the γδ T cell.
- Genetic engineering: Using genetic modification technology to introduce specific receptors into γδ T cells. This can enhance its specificity and targeting ability towards cancer cells.
- Gene transfer: Introducing genetic modifications into γδ T cells using viral vectors, electroporation, or other gene transfer methods.
Alfa Cytology also excels in enhancing targeting strategies, such as developing bispecific antibodies and antibody drug conjugates.
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γδ T cells have great potential in the field of immunotherapy, providing enormous potential for the therapy of leukemia. Alfa Cytology is committed to research and technology related to γδ T cells, paving the way for more effective and personalized treatment strategies. Contact us immediately to discuss your project or inquire about our γδ T cell-related services. Our team is eager to collaborate and help you turn therapeutic innovation into reality.
Reference
- Yazdanifar, M.; et al. γδ T Cells: The Ideal Tool for Cancer Immunotherapy. Cells 2020, 9, 1305. https://doi.org/10.3390/cells9051305