In Vitro Pharmacology Services
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In Vitro Pharmacology Services

Alfa Cytology is a company that supports drug discovery and development. In drug development for leukemia, we have an experienced team to provide you with high-quality in vitro pharmacodynamic services. Our team continues to improve the development of in vitro drug detection methods, focusing on the identification, characterization, and verification of small and macromolecules acting on leukemia in vitro. We provide high-quality data on drug safety and efficacy to support your subsequent drug development process.

Introduction to In Vitro Pharmacology

In vitro pharmacology pertains to the investigation of drug effects on cells outside of a living organism. The aim of in vitro pharmacological studies is to assess the impact and efficacy of drugs under experimental conditions, enabling an understanding of their pharmacological characteristics, toxicity, and effectiveness. This type of research typically occurs during the early stages of drug development, with the goal of screening and evaluating the activity, selectivity, and safety of potential drug molecules.

Fig. 1. Schematic representation of cell-sensitivity assays. (Capula, M. et al., 2019)

Our Services

In vitro pharmacology studies the effects of drugs on cells, tissues, or organs using artificial systems outside the body of an organism. In vitro testing can also help understand mechanisms of action, identify targets, and optimize drug candidates. Alfa Cytology provides comprehensive in vitro pharmacology services for leukemia therapy development, including but not limited to the following.

Selection of Leukemia Cell Line

In vitro evaluation of new drug development for leukemia, we will choose a suitable cell line model for you. We offer the classic leukemic cell lines. Characteristics and responses vary from cell line to cell line, and selecting the cell line that most closely resembles a specific target ensures more accurate results.

  • K562
  • REC-1
  • Jurkat
  • HL-60
  • Karpas 422
  • MV-4-11
  • KASUMI-1
  • MOLM14
  • HAL-01
  • THP-1
  • karpas 299
  • CCRF-CEM
  • OCI-LY19

Custom in Vitro Pharmacology Services

Based on the cell lines and project requirements of your experiments, we offer corresponding testing services tailored to your needs. Our comprehensive in vitro pharmacology screening suite provides you with a thorough understanding of your compounds. We delve into the mechanisms and interactions to enable informed decision-making regarding their potential.

  • Cell-Survival and Cell Growth-Inhibition Assays
  • Phenotypic Screening Services
  • Protein Interaction Detection
  • Study the Drug Mechanism in Leukemia
  • Leukemic Cell Detection
  • Enzyme Inhibition Experiment
  • Ion Channels Assays
  • Biochemical Assays

Evaluation and Research in Different Therapy

We are dedicated to evaluating and researching therapies for leukemia, actively building our capabilities in drug efficacy assessment. We have established models and expertise in evaluating the efficacy of various treatment approaches, backed by extensive project service experience. We provide diverse solutions for different types of models, encompassing but not limited to the following aspects.

Small MoleculesNatural CompoundsTherapeutic AntibodyAntibody Drug Conjugates
Cell TherapyGene TherapyTherapeutic Vaccine

Advantages of Our Services

  • The most advanced testing instruments and technologies
  • High throughput screening automation system
  • Solve the problem of different types of drugs
  • Customized leukemic cell model for in vitro pharmacodynamic experiment

Based on the developed leukemia cell model, Alfa Cytology provides in vitro drug testing services in leukemia, covering a variety of cell testing. The experimental results we deliver to you support you in evaluating the efficacy and efficacy of the drug against leukemia, the safety and toxicity of the drug, and the mechanism of action of the drug. Please contact us if you are interested in our services or would like to know more.

Reference

  1. Capula, M.; et al. A brief guide to performing pharmacological studies in vitro: Reflections from the EORTC-PAMM Course "Preclinical and Early-phase Clinical Pharmacology". Anticancer Research. 2019, 39(7): 3413-3418.
For research use only. Not intended for any clinical use.