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Oncolytic viral therapy refers to using a replication-competent virus to treat cancer. It is recognized that oncolytic viruses can function through multiple roles, including mutations in the tumor environment and combined changes in the action of immune effectors. Alfa Cytology is a world leader in cancer therapy development. With our extensive experience and advanced platform, we can provide the best solutions for oncolytic viral therapy development.
Because hematological malignancies are difficult to treat and have a high recurrence rate, and there is evidence of contaminated cancer cells in transplantation, removal of contaminated cancer cells is an effective way to improve overall survival after transplantation. Due to the special properties of OVS, they are considered ideal scavengers for hematological malignancies. For example, oncolytic viruses can re-engineer the pro-tumor environment into an inflammatory and anti-tumor environment by affecting tumor-associated cells such as fibroblasts, macrophages, endothelial cells, and neutrophils. Some of the oncolytic virus types in the study and the types of cancers these viruses correspond to are listed below.
|
Viruses |
Cancer |
|---|---|
| Measles Virus | T-cell lymphoma |
| Reovirus | Multiple myeloma |
| Vesicular Stomatitis Virus | Acute myeloid leukemia (AML) |
| Vaccinia Virus | B-cell lymphoma |
Oncolytic viruses selectively destroy tumor cells through two main mechanisms.
Modern genetic engineering techniques can increase the tumor specificity of viruses and regulate their immunogenicity by enhancing their replication activity in tumor cells. At present, the development and research of novel oncolytic virus strains are developing rapidly.
Fig. 1 Oncolytic virus anti-tumor mechanism of action. (Lovatt, C. & Parker, A.L.; 2023)
The natural oncolytic properties of viruses were discovered more than a century ago, and advances in the understanding of molecular mechanisms and viral biology have facilitated the development of effective and highly selective oncolytic strains. Oncolytic viruses can continuously infect tumor cells and eliminate small residual lesions, so oncolytic virus therapy has great potential in leukemia, such as AML.
| Indication | Therapeutics | Company | Phase |
|---|---|---|---|
| T Cell Lymphoma | Voyager-V1 | Vyriad | |
| Multiple Myeloma | Voyager-V1 | Vyriad |
With our specialized laboratories and development platform, Alfa Cytology provides customized, standardized, reliable, and high-quality oncolytic virus therapy development services for leukemia.
Oncolytic Virus Construction
We conducted a comprehensive analysis of diverse viruses, considering their characteristics, infectivity, potential functions, and applicability. We have refined our customized process for oncolytic viruses to accommodate a range of virus types, including adenovirus, herpes simplex virus, measles virus, vaccinia virus, and vesicular stomatitis virus. Alfa Cytology offers a variety of customized oncolytic viruses formulated to target different types of leukemia.
Oncolytic Virus Engineering
Using the core anti-cancer mechanisms of oncolytic viruses and the inherent properties of different viruses, we have pioneered a variety of optimized engineering methods. Based on a wide range of immune-related expertise, Alfa Cytology focuses on the engineering of oncolytic viruses to improve their specificity to target tumors, promote cell lysis, and optimize the strength of anti-cancer immune responses.
Oncolytic Virus Characterization
We have detailed in vitro and in vivo preclinical validation protocols for each oncolytic virus. In addition, validation services are strictly customized according to factors such as the characteristics of the targeted disease, the attributes of the virus, and the mechanism of action. Through sophisticated validation analyses, Alfa Cytology optimizes oncolytic virus therapy and improves safety and efficacy in the fight against cancer.
Customized
Solutions
Regulatory
Compliance
Timely
Delivery
Highly
Confidential
Alfa Cytology is committed to the research and study of cancer and provides one-stop services. Our cancer experts have many years of experience in the latest therapies for oncolytic viral therapy. If you are interested in our service, please contact us for more information.
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