Macrophages exhibit a wide range of phenotypes and functions depending on their activation state within the tumor microenvironment. At Alfa Cytology, we take pride in offering exceptional services in the field of macrophage-based assays, catering to the diverse needs of biology experts in cancer research.
Introduction to Macrophage Polarization
One prominent area of investigation is the polarization of macrophages into distinct phenotypes, namely M1 and M2. M1 macrophages possess an anti-tumor phenotype, promoting inflammation and immune response against cancer cells. On the other hand, M2 macrophages exhibit pro-tumor characteristics, facilitating tumor growth, angiogenesis, and immune suppression. Understanding the balance between M1 and M2 macrophages and their impact on tumor progression is crucial for designing effective cancer therapies.
Fig.1 The polarization of macrophages. (Rhee, I., et al., 2016)
Our Services
Alfa Cytology offers a comprehensive range of macrophage-based assays to support cancer research and drug development. Our services are designed to provide researchers with in-depth characterization and functional evaluation of macrophages in the context of cancer. Our services include, but are not limited to:
Macrophage Polarization
Assays
By analyzing specific markers and functional readouts, our assays provide quantitative and qualitative data on macrophage polarization. We enable our clients to assess the immunosuppressive or anti-tumor potential of the tumor-associated macrophages and identify potential therapeutic targets.
Macrophage-Tumor Cell Interaction
Assays
Alfa Cytology offers co-culture assays that allow researchers to investigate the effects of macrophages on tumor cell proliferation, invasion, metastasis, and immune evasion. We provide valuable insights into the tumor-promoting or tumor-inhibiting properties of macrophages.
Macrophage Functional
Assays
Our assays include assessments of migration, phagocytosis, cytokine production, antigen presentation, and immune checkpoint expression. We enable researchers to elucidate the mechanisms by which macrophages modulate the tumor microenvironment.
Alfa Cytology offers a range of macrophage-based assays to support clients in their quest to unravel the intricacies of macrophage biology and develop innovative cancer therapies. If you are interested in our service, please contact us for more details.
Reference
- Rhee, I. (2016). Diverse macrophages polarization in tumor microenvironment. Archives of pharmacal research, 39(11), 1588-1596.
! For research use only.
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