Metastasis Tumor Model Development Services
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Metastasis Tumor Model Development Services

Metastatic tumor models are important experimental tools used to study the process of tumor metastasis. Alfa Cytology is committed to providing our clients with one-stop metastasis tumor model development services. Our goal is to provide reliable, reproducible, and translatable models that accurately reflect human disease, to accelerate the process of translating from the lab to therapy.

Introduction to Metastasis Tumor Model

Tumor metastasis is a continuous cascade process involving multiple factors, in which only a very small number of tumor cells survive in circulation and undergo lethal metastasis. The use of the human body itself as an experimental object to delve into the mechanisms of disease occurrence to advance medicine has been slow; the accumulated clinical experience is not only limited in time and space but also many experiments are morally and methodologically restricted. Indirect studies with the help of animal models can observe the experimental results of models more accurately and conduct comparative studies with human diseases, which can help to understand the developmental patterns of human diseases more conveniently and effectively in order to study the prevention and control measures. It is a good research tool, especially in tumor and microenvironment-related studies.

Fig.1 Metastasis Tumor Model.Fig.1 Stages of metastatic progression in pancreatic cancer. (Miquel, M., Zhang, S., & Pilarsky, C., 2022)

Advantages of Metastasis Tumor Model

Tumor metastasis is a key component of cancer progression and is usually closely associated with prognosis and survival. The in-depth study of metastatic tumor models helps us to understand the biological mechanisms of metastasis, the ability of tumor cells to adapt to new environments, and the impact of changes in the microenvironment on metastasis.

Reflecting the Metastatic Process

Metastatic tumor models are able to simulate the real biological process of tumor cell metastasis, providing valuable data on metastatic mechanisms and tumor microenvironment interactions.

Evaluating Treatment Effectiveness

These models can be used to evaluate the efficacy of different treatment regimens for metastatic tumors, providing critical data for new drug development, especially in therapeutic studies for metastatic disease.

Diverse Research Applications

Metastatic tumor models are applicable to a wide range of tumor types and can help researchers explore the metastatic characteristics and potential targets of different tumor types.

Our Services

Metastatic tumor animal models can provide a better research platform for tumor metastasis research, and also provide a good experimental tool for the study of the role of tumor microenvironment in tumor development and treatment, as well as the development of anti-tumor metastatic drugs. At Alfa Cytology, we have established a proven technology platform designed to provide our global customers with efficient and effective tumor metastatic models for tumor research and anti-tumor drug development.

Customized Metastatic Tumors

Alfa Cytology breaks down experimental and technical barriers to provide customized animal models of metastatic tumors, which include but are not limited to the following. These models simulate the mechanisms by which tumor cells migrate from their primary site to other organs, helping researchers gain a deeper understanding of the biological mechanisms of metastasis and its impact on treatment.

Tumor types Cell line Inoculate Metastasis
Melanoma B16 Intravenous Lung, Liver, Kidney, Heart
Liver Cancer HCCLM3 Liver Stomach, Lymph Nodes
Stomach Cancer MKN-45 Stomach Liver, Lymph Nodes
Bowel Cancer HT-29 Spleen Liver, Lymph Nodes
Bowel Cancer HCT-116 Cecum Liver, Lymph Nodes
Prostate Cancer PC-3 Intracardiac Bone
Lung Cancer A549 Intravenous Lung, Liver
Lung Cancer LL/2 Intravenous Lung
Breast Cancer 4T1 Breast pads Lung, Kidney

Workflow of Metastasis Tumor Model Development

Consultation and Project Planning

Understand your specific needs and outline the project scope.

Model Selection and Construction

Suitable tumor cell lines are selected to establish metastasis models.

Metastasis Monitoring

Regularly detect metastasis of tumor cells to assess metastatic characteristics and treatment response.

Data Analysis and Reporting

Provide detailed reports including information on metastasis, tumor growth, and drug response.

Support and Consultation

Help clients understand the data and discuss the subsequent experimental design.

With extensive experience in various cancer models and expertise in tumor and microenvironment, Alfa Cytology is the ideal partner to support your oncology therapeutic research. We provide customers with stock model products, model customization, and joint R&D services to provide you with the best tumor models and look forward to meeting your precise needs. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.

Reference

  1. Miquel, M., Zhang, S., & Pilarsky, C. (2021). Pre-clinical models of metastasis in pancreatic cancer. Frontiers in cell and developmental biology, 9, 748631.

For research use only.