Oncogenic Signaling Pathway Analysis
Analyzing oncogenic signaling pathways provides valuable insights into the underlying molecular mechanisms and facilitates the development of targeted therapeutic strategies. At Alfa Cytology, we specialize in oncogenic signaling pathway analysis, offering comprehensive services to advance cancer research and drug discovery.
Introduction to Oncogenic Signaling Pathway
The oncogenic signaling pathway refers to a complex network of molecular interactions and signaling cascades that are aberrantly activated in cancer cells, leading to uncontrolled cell growth, evasion of apoptosis, angiogenesis, invasion, and metastasis. These pathways are often dysregulated due to genetic alterations, including gene mutations, amplifications, and chromosomal rearrangements. Several well-known oncogenic signaling pathways have been extensively studied, including the Wnt/β-catenin, Ras/MAPK, PI3K/Akt/mTOR, Notch, and Hedgehog pathways.
Fig.1 Oncogenic Signaling Pathways in The Cancer Genome Atlasl. (Sanchez-Vega, F., et al., 2018)
Our Services
At Alfa Cytology, we pride ourselves on providing tailored solutions to meet the unique needs of our clients in the field of oncogenic signaling pathway analysis. Our team of expert biologists and scientists are dedicated to delivering comprehensive insights and actionable results. We offer a range of customizable services that help unravel the molecular mechanisms driving cancer development and progression. Our services include, but are not limited to:
Genomic
Analysis
We employ genomic techniques, such as next-generation sequencing (NGS), to identify and characterize genetic alterations within oncogenic signaling pathways. We can pinpoint somatic mutations, gene amplifications, deletions, and fusion events that contribute to oncogenesis.
Protein Expression
Profiling
We utilize proteomic technologies, including mass spectrometry and immunohistochemistry, to perform comprehensive protein expression profiling. This enables us to identify key signaling molecules, assess their activation status, and determine their subcellular localization in cancer cells and tissues.
Functional Assays and Pathway
Analysis
At Alfa Cytology, we offer a wide range of functional assays to evaluate the impact of oncogenic signaling pathways on cellular processes. These include cell proliferation assays, apoptosis assays, migration and invasion assays, angiogenesis assays, and stem cell-like properties assays.
Our Advantages
Largest Toolbox
Strong Expertise
One-stop Solution
Short Turnaround
At Alfa Cytology, we offer comprehensive services to provide a holistic understanding of oncogenic signaling pathways. With our expertise and collaborative approach, we enable researchers and pharmaceutical companies to advance their understanding of cancer biology and accelerate the development of targeted therapies. If you are interested in our service, please contact us for more details.
Reference
- Sanchez-Vega, F., et al.; (2018). Oncogenic signaling pathways in the cancer genome atlas. Cell, 173(2), 321-337.
For research use only.
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