Oncolytic Viral Therapy Development Services

Introduction to Oncolytic Viral Therapy

Since the first attempt to use viruses to treat tumors in the 20th century, oncolytic virus therapy has been extensively and deeply studied in cancer therapy. These viruses offer a novel therapy by selectively targeting and destroying cancer cells while preserving healthy tissue. While some viruses are less popular, many can be effectively engineered based on their infectivity and ability to carry engineered DNA or RNA fragments. In addition to the direct oncolytic effect of selective infection of lytic tumor cells, oncolytic viruses can also mediate the release of virus-associated antigens and tumor neoantigens and finally activate the anti-tumor immunity to achieve the effect of killing the tumor.

Fig.1 Multimodal mechanisms of action associated with oncolytic virus therapy. (Kaufman, H.L. & Maciorowski, D., 2021)

Oncolytic Virus Therapy Development for Different Cancer

The oncolytic virus is an anticancer agent that can replicate in lytic malignant cells without infecting healthy cells. In general, oncolytic viruses are used in cancer treatment in three main ways.

• Some oncolytic viruses can essentially exploit cellular defects that promote tumor growth.
• Some oncolytic viruses can be engineered to take advantage of tumor-specific mutations that occur frequently in antiviral defense programs or to rely on signaling pathways that are compositionally activated in tumors.
• Based on the expression of specific antigens on the surface of tumor cells.

Therefore, when developing disease-specific oncolytic virus treatment strategies, it is important to consider both cancer immunology and the characteristics of the selected virus.

Current Status of Oncolytic Viral Therapy Development

Oncolytic virus therapy has the characteristics of immunotherapy, targeted therapy, and gene therapy, and is expected to become a new generation of anti-cancer tools. Oncolytic viral therapy has been tested in clinical trials in many cancers.

Our Services

With our specialized laboratories and development platform, Alfa Cytology provides customized, standardized, reliable, and high-quality oncolytic virus therapy development services to worldwide customers. Our services cover everything from virus engineering and cell biology to animal testing. Various types of oncolytic virus engineering systems have been established in-house to facilitate the development of oncolytic virus therapies in a shorter time and at a lower budget.

Why Choose Us?

Alfa Cytology is committed to the research and study of cancer and provides one-stop services. Our cancer experts have many years of experience in the latest therapies for oncolytic viral therapy. If you are interested in our service, please contact us for more information.

! For research use only.