Organoid Model Development Services

Organoids are self-organizing three-dimensional structures derived from primary tissues or stem cells that closely mimic the cellular composition and organization of specific organs. In the context of cancer research, tumor organoids represent a valuable platform for studying tumor initiation, progression, metastasis, and therapeutic responses. At Alfa Cytology, we leverage state-of-the-art techniques to develop organoid models that faithfully recapitulate the characteristics of tumors in vivo.

Introduction into Organoid Model

Traditional in vitro models often fail to capture the complex cellular architecture, functional heterogeneity, and microenvironmental cues of tumors, limiting their translational relevance and utility in drug discovery and personalized medicine. Organoid models address these limitations by providing researchers with a physiologically relevant platform for studying tumor biology and evaluating therapeutic interventions.

Fig.1 The establishment of organoid-based culture. (Zhao, Z., et al., 2022)

The adaption of protocols to generate organoids from human ASCs allowed the derivation of cancer organoids from patient material, typically surgical specimen or needle biopsies. Establishment of cancer organoid cultures has been described for primary and/or metastatic tumor tissue sampled from the bladder, brain, breast, colon, endometrium, head and neck, kidney, liver, lung, oesophagus, ovaries, pancreas, prostate, rectum, and stomach.

Fig.2 Generation of patient-derived normal and cancer organoids. (Bogoslowski, A., et al., 2021)

Organoids are tiny three-dimensional cultures derived from tissue or pluripotent stem cells. Using knowledge gained from maintaining stem cell populations, cells are cultured in an environment that allows them to follow their own genetic instructions and self-organize into tissues with certain organ-like functions that contain self-renewing stem cell populations. Self-assembly and differentiation are the result of directive signaling to the cells from the extracellular matrix, the culture medium, and the cell types present in the organoid itself after the structure has been assembled.

Our Services

Our Organoid Model Development Services offer researchers a versatile and customizable platform for studying various aspects of tumor biology, including tumor growth, invasion, metastasis, angiogenesis, and drug response. By leveraging our innovative technology, we empower researchers to create organoid models derived from patient samples or engineered to mimic specific tumor types, enabling the study of individual patient responses to treatment and the development of personalized medicine approaches.

At Alfa Cytology, we are committed to advancing cancer research and therapeutic development through innovative modeling solutions. With a multidisciplinary team of experts and state-of-the-art facilities, we empower researchers and pharmaceutical companies to unlock new insights and transform cancer care. Contact us today to learn more about our Cancer Modeling Services and start your journey towards groundbreaking discoveries.

For research use only.