6-Diazo-5-oxo-L-nor-Leucine
Catalog No.: PC0073
Size: 1 mg,5 mg, 10 mg, 50mg
Description
6-Diazo-5-oxo-L-nor-Leucine is a glutamine antagonist that irreversibly inhibits glutamine catabolism. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic ability of tumor cells. 6-Diazo-5-oxo-L-nor-Leucine also has antibacterial and antiviral activity.
| Molecular Weight |
171.15 |
| Formula |
C6H9N3O3 |
| CAS No. |
157-03-9 |
| Appearance |
Solid |
| Color |
Off-white to light yellow |
| SMILES |
N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O |
| Shipping |
Room temperature in continental US; may vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| In Vitro |
6-Diazo-5-oxo-L-nor-Leucine (DON) (0.3 mM; 1 h) shows inhibition of glutamine catabolism in WI-L2 cells.
6-Diazo-5-oxo-L-nor-Leucine (DON) decreases the selfrenewal potential and metastatic ability of tumor cell. |
| In Vivo |
6-Diazo-5-oxo-L-nor-Leucine sensitizes pancreatic tumors to anti-PD1 resulting in tumor regression and prolonged survival in vivo.
6-Diazo-5-oxo-L-nor-Leucine decreases hyaluronan and collagen in the tumor microenvironment, leading to an extensive remodeling of the ECM (extensive extracellular matrix), and an increases infiltration CD8+ T-cells. |
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use only and cannot be used to diagnose, treat or manage patients.
