Almorexant hydrochloride

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Almorexant hydrochloride

Catalog No.: PC0175

Size: 1 mg, 5 mg,10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Description

Almorexant (ACT 078573) hydrochloride is an orally active, potent, and competitive dual orexin receptor antagonist that reversibly blocks signaling by orexin-A and orexin-B peptides. Almorexant hydrochloride completely blocks the intracellular Ca2+ signaling pathway. Almorexant hydrochloride stimulates caspase-3 activity and induces apoptosis in AsPC-1 cells.

Molecular Weight	549.02
Formula	C29H32ClF3N2O3
CAS No.	913358-93-7
Appearance	Solid
Color	White to off-white
SMILES	CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	Almorexant (1 μM) promotes tyrosine phosphorylation of SHP2/OX1R complex. Almorexant (1 μM) inhibits the cellular growth of AsPC-1 cells.
*In Vivo*	Almorexant (1.8 μmol/kg, 100 μL; IP, daily) reduces the volume of tumors. Almorexant (300 mg/kg, PO, once) can help rats to be fully capable of spatial and avoidance learning. Almorexant (30-300 mg/kg) dose-dependently increases rapid eye movement (REM) and non-REM (NREM) sleep and decreases wakefulness apparently without inducing either cataplexy18 or deficits in next-day performance.

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