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Antitumor agent-91

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Antitumor agent-91

Antitumor agent-91

Catalog No.: PC0091

Size: 50 mg, 100mg, 250mg.

Description

Antitumor agent-91 is a cyclic phosphate derivative with anticancer and antiproliferative activities and has potential application in human castration-resistant prostate cancer and pancreatic cancer.

Molecular Weight 473.32
Formula C18H18F2N3O8P
SMILES O=C(COP1(O[C@@H](C(F)(F)[C@H](N2C=CC(N)=NC2=O)O3)[C@H]3CO1)=O)OCC4=CC=CC=C4
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro Antitumor agent-91 (Compound 18c) has anti-tumor activity against MM1. S, BxPC-3, MP-2, 22Rv1, MV4-11, Jeko-1 and HUH7 cells with IC50 values of 3.6 nM, 16.5 nM, 12.5 nM, 10.6 nM, 5.4 nM, 19.2 nM and 16.2 nM, respectively.
In Vivo Antitumor agent-91 (Compound 18c) (50 mg/kg; i.p.; twice a week for four weeks) significantly inhibits tumor growth in a castrated male Balb/c nude mouse model implanted with 22Rv1 tumor.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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