Bazedoxifene acetate

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Catalog No.: PC0141

Size: 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Description

Bazedoxifeneacetate (TSE-424acetate) is an oral, non-steroidal selective estrogen receptor modulator. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interaction and may be useful in pancreatic cancer research.

Molecular Weight	530.65
Formula	C32H38N2O5
CAS No.	198481-33-3
Appearance	Solid
Color	White to off-white
SMILES	CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51.CC(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	Bazedoxifene acetate is a small molecular GP130 inhibitor, which binds to GP130 D1 domain. Bazedoxifene acetate inhibits STAT3 phosphorylation induced by Il-6 and IL-11 in GP130/STAT3 pathway signaling. Bazedoxifene acetate (10 μM-20 μM; 2 hours) inhibits STAT3 Phosphorylation Induced by cytokines in human pancreatic cancer cells. Bazedoxifene acetate (5-20 μM; overnight) induces apoptosis in human pancreatic cancer cells. Bazedoxifene acetate inhibits STAT3 nuclear translocation induced by IL-6. Bazedoxifene acetate blocks the cells migration in pancreatic cancer cells by inhibition of GP130.
*In Vivo*	Bazedoxifene acetate (5 mg/kg; i.g.; daily, for 18 days) inhibits Capan-1 tumor growth in mouse model in vivo.

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