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Benzyl-α-GalNAc

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Benzyl-α-GalNAc

Benzyl-α-GalNAc

Catalog No.: PC0078

Size: 5 mg,10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and inhibits the expression of type I/III collagen, showing good potential in liver fibrosis research. Benzyl-α-GalNAc also significantly enhances the antitumor activity of 5-FU (HY-90006) (e.g., pancreatic cancer) by inhibiting O-glycosylation.

Molecular Weight 311.33
Formula C15H21NO6
CAS No. 3554-93-6
Appearance Solid
Color White to off-white
SMILES O[C@@H]([C@H]([C@@H](CO)O1)O)[C@@H](NC(C)=O)[C@H]1OCC2=CC=CC=C2
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro Benzyl-α-GalNAc (5 mM; 72 h) inhibits O-glycosylation of mucin in SUIT-2 cells.
Benzyl-α-GalNAc (2, 4 mM; 48 h) inhibits the proliferation and activation of LX-2 cells.
Benzyl-α-GalNAc (2, 4 mM; 48 h) decreases collagen expression in LX-2 cells.
In Vivo Benzyl-α-GalNAc (1 mg/mice; tumoural injection; single daily; days 4, 6, 8 and 10 after tumour size reaches 50-70 mm3) enhances the anti-tumour activity of 5-FU by inhibiting O-glycosylation in mice.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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