CFPAC-1

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Catalog No.: PC0010

Description

CFPAC-1 is a ductal pancreatic adenocarcinoma that was generated by differential trypsin digestion of explant cultures of liver metastatic lesions in a 26-year-old white man with cystic fibrosis (CF). This cell line expresses cystic fibrosis transmembrane regulator (CFTR) and has ion transport properties consistent with CF deficiency. CFPAC-1 cells display epithelial morphology and polarization, with apical microvilli. Expression of cytokeratin and carcinoembryonic antigen characteristic of pancreatic duct cells has been described. These cells express the CF gene and display the most common CF mutation, a deletion of three nucleotides resulting in the deletion of phenylalanine 508. CFPAC-1 cells are also tumorigenic in nude mice.

Origin	Human caucasian pancreatic adenocarcinoma
Application	Cystic fibrosis studies, genetic analysis
Biological Source	Human pancreas (liver metastasis)
Growth Mode	Adherent
Karyotype	Hyperdiploid, (65-75 chromosomes)
Morphology	Epithelial
Products	Not specified
Receptors	Cystic fibrosis trans-membrane regulator (CFTR)
Technique	Cell culture, suitable for mammals.
Relevant Disease	Metastasis
Shipped In	Dry ice
Culture Medium	IDMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).

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