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d-Sophoridine

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d-Sophoridine

d-Sophoridine

Catalog No.: PC0127

Size: 5 mg,10 mg, 50 mg

Description

d-Sophoridine ((+)-Sophoridine) is the dextrorotary isomer of Sophoridine (HY-N1373) and induces apoptosis. Sophoridine has the potential to become a new, effective, and selective anti-tumor drug candidate for pancreatic cancer with good toxicity tolerance.

Molecular Weight 248.36
Formula C15H24N2O
CAS No. 83148-91-8
SMILES O=C(CCC1)N2[C@]1([H])[C@@](CCCN3CCC4)([H])[C@@]3([H])[C@]4([H])C2
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM.
Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively.
Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.
In Vivo Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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